Antiemetic Prophylaxis for Chemotherapy-Induced Nausea and Vomiting
One of the most important changes in cancer treatment in recent decades has been the development of treatment regimens that greatly reduce the incidence and intensity of nausea and vomiting. The most effective regimens and how they work are reviewed. Chemotherapy-induced nausea and vomiting (chemoth...
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Veröffentlicht in: | The New England journal of medicine 2016-04, Vol.374 (14), p.1356-1367 |
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Sprache: | eng |
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Zusammenfassung: | One of the most important changes in cancer treatment in recent decades has been the development of treatment regimens that greatly reduce the incidence and intensity of nausea and vomiting. The most effective regimens and how they work are reviewed.
Chemotherapy-induced nausea and vomiting (chemotherapy-induced emesis) is a common treatment-related side effect that has a detrimental effect on the quality of life of patients with cancer and may lead to dose reductions in or discontinuation of chemotherapy. The development of new antiemetic agents has dramatically changed the landscape of chemotherapy-induced emesis. In the 1970s, prolonged hospital stays for nausea after chemotherapy were common practice.
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In 1979, a randomized trial involving patients with cancer showed that the overall incidence of chemotherapy-induced emesis was approximately 83%.
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Two decades later, with newly available antiemetics, an observational study reported incidences of acute nausea and . . . |
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ISSN: | 0028-4793 1533-4406 |
DOI: | 10.1056/NEJMra1515442 |