Effect of 5-Fluorouracil on Thymidine Phosphorylase Activity in Model Experiment

Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2016-03, Vol.160 (5), p.646-648
Hauptverfasser:	Stashkevich, M. A., Khomutov, E. V., Dumanskii, Yu. V., Matvienko, A. G., Zinkovich, I. I.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents - pharmacology Biomedical and Life Sciences Biomedicine Cancer Cell Biology Chemotherapy Enzymes Fluorouracil Fluorouracil - pharmacology Internal Medicine Laboratory Medicine Liver Liver - metabolism Male Pathology Pharmacology and Toxicology Pyrimidine nucleotides Rats Rats, Wistar Thymidine Phosphorylase - metabolism
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Zusammenfassung:	Variations in thymidine phosphorylase activity in rat liver were studied in 1, 3, 6, 12, and 24 h after intraperitoneal bolus injection of 5-fluorouracil. Enzyme activity was measured by HPLC. A 2-fold decrease in enzyme activity was observed 3 h after 5-fluorouracil administration and persisted for 12 h. This additional effect of the cytostatic should be taken into account in choosing chemotherapy protocol.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-016-3239-z