Statin therapy is not associated with improved outcomes after heart transplantation in children and adolescents

Statin therapy is not associated with improved outcomes after heart transplantation in children and adolescents

Background Although used routinely, the pleiotropic benefits of statins remain understudied in children after heart transplantation. We hypothesized that statin therapy would reduce the incidence of rejection, cardiac allograft vasculopathy (CAV) and post-transplant lymphoproliferative disease (PTLD...

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Veröffentlicht in:The Journal of heart and lung transplantation 2016-04, Vol.35 (4), p.457-465
Hauptverfasser: Greenway, Steven C., MS, MD, FRCPC, Butts, Ryan, MD, Naftel, David C., PhD, Pruitt, Elizabeth, MSPH, Kirklin, James K., MD, Larsen, Ingrid, BScN, Urschel, Simon, MD, Knecht, Kenneth, MD, Law, Yuk, MD
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Child
Child, Preschool
Female
Follow-Up Studies
Graft Rejection - drug therapy
Graft Rejection - epidemiology
Graft Survival
Heart Transplantation
HMG-CoA reductase inhibitors
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Incidence
Male
pediatric heart transplantation
PTLD
Registries
rejection
Retrospective Studies
Risk Factors
statin
Surgery
Survival Rate - trends
Time Factors
United Kingdom - epidemiology
United States - epidemiology
vasculopathy
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Zusammenfassung:Background Although used routinely, the pleiotropic benefits of statins remain understudied in children after heart transplantation. We hypothesized that statin therapy would reduce the incidence of rejection, cardiac allograft vasculopathy (CAV) and post-transplant lymphoproliferative disease (PTLD). Methods This study was a retrospective review of 964 pediatric (ages 5 to 18 years) heart transplant recipients in the multicenter Pediatric Heart Transplant Study registry from 2001 to 2012. Patients were excluded if they were undergoing re-transplantation, survived
ISSN:1053-2498
1557-3117
DOI:10.1016/j.healun.2015.10.040