Regulation of neuron–astrocyte metabolic coupling across the sleep–wake cycle

Regulation of neuron–astrocyte metabolic coupling across the sleep–wake cycle

Highlights • Astrocytes adjust local energy production to neuronal energy needs. • The “neurometabolic coupling” (NMC) mechanisms interact with sleep regulation. • Astrocyte network plays a role in sleep/NMC interactions. • Astrocytic NMC fit the “local and use dependent” sleep hypothesis....

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Veröffentlicht in:Neuroscience 2016-05, Vol.323, p.135-156
Hauptverfasser: Petit, J.-M, Magistretti, P.J
Format: Artikel
Sprache:eng
Schlagworte:
adenosine
Animals
Astrocytes - metabolism
gap-junctions
glucose
glutamate
Humans
lactate
locus coeruleus
Neurology
Neurons - metabolism
Sleep - physiology
Wakefulness - physiology
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Zusammenfassung:Highlights • Astrocytes adjust local energy production to neuronal energy needs. • The “neurometabolic coupling” (NMC) mechanisms interact with sleep regulation. • Astrocyte network plays a role in sleep/NMC interactions. • Astrocytic NMC fit the “local and use dependent” sleep hypothesis.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.12.007