National trends of acute kidney injury requiring dialysis in decompensated cirrhosis hospitalizations in the United States

Background and aims Cirrhosis affects 5.5 million patients with estimated costs of US$4 billion. Previous studies about dialysis requiring acute kidney injury (AKI-D) in decompensated cirrhosis (DC) are from a single center/year. We aimed to describe national trends of incidence and impact of AKI-D...

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Veröffentlicht in:Hepatology international 2016-05, Vol.10 (3), p.525-531
Hauptverfasser: Nadkarni, Girish N., Simoes, Priya K., Patel, Achint, Patel, Shanti, Yacoub, Rabi, Konstantinidis, Ioannis, Kamat, Sunil, Annapureddy, Narender, Parikh, Chirag R., Coca, Steven G.
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Sprache:eng
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Zusammenfassung:Background and aims Cirrhosis affects 5.5 million patients with estimated costs of US$4 billion. Previous studies about dialysis requiring acute kidney injury (AKI-D) in decompensated cirrhosis (DC) are from a single center/year. We aimed to describe national trends of incidence and impact of AKI-D in DC hospitalizations. Methods We extracted our cohort from the Nationwide Inpatient Sample (NIS) from 2006–2012. We identified hospitalizations with DC and AKI-D by validated ICD9 codes. We analyzed temporal changes in DC hospitalizations complicated by AKI-D and utilized multivariable logistic regression models to estimate AKI-D impact on hospital mortality. Results We identified a total of 3,655,700 adult DC hospitalizations from 2006 to 2012 of which 78,015 (2.1 %) had AKI-D. The proportion with AKI-D increased from 1.5 % in 2006 to 2.23 % in 2012; it was stable between 2009 and 2012 despite an increase in absolute numbers from 6773 to 13,930. The overall hospital mortality was significantly higher in hospitalizations with AKI-D versus those without (40.87 vs. 6.96 %; p  
ISSN:1936-0533
1936-0541
DOI:10.1007/s12072-016-9706-9