Amorphous calcium phosphate, hydroxyapatite and poly(d,l-lactic acid) composite nanofibers: Electrospinning preparation, mineralization and in vivo bone defect repair

[Display omitted] •Amorphous calcium phosphate, hydroxyapatite and PLA composite nanofibers are prepared.•The composite nanofibers show enhanced in-situ mineralization.•This composite nanofibers have good surface properties and high biocompatibility.•This composite nanofibers can be used in bone defect repair. Due to the outstanding bioactivity and biocompatibility, calcium phosphate (CaP) based materials have been widely investigated for applications in the biomedical fields. In this study, amorphous calcium phosphate (ACP) nanospheres and hydroxyapatite (HA) nanorods have been prepared and hybridized with poly(d,l-lactic acid) (PLA) to fabricate the composite nanofibers through electrospinning. The as-prepared ACP-PLA and HA-PLA composite nanofibers exhibit favorable mineralization behaviors in simulated body fluid (SBF). In the mineralization process, the ACP nanospheres and HA nanorods play an important role in the formation of HA nanosheets on the surface of composite nanofibers. The ACP-PLA and HA-PLA composite nanofibers show a high biocompatibility. The in vivo bone defect repair properties of the ACP-PLA and HA-PLA composite nanofibers are preliminarily investigated. The as-prepared ACP-PLA and HA-PLA composite nanofibers have promising applications in the biomedical fields.