Copper-Catalyzed Aromatic CH Bond Cyanation by CCN Bond Cleavage of Inert Acetonitrile

Copper-Catalyzed Aromatic CH Bond Cyanation by CCN Bond Cleavage of Inert Acetonitrile

Cut and paste! A Cu‐catalyzed aromatic CH cyanation with acetonitrile as the nitrile source by CCN cleavage has been developed (see scheme; TMEDA=N,N,N′,N′‐tetramethylethylenediamine). The reaction is catalytic in copper, and it is found that using (Me3Si)2 as an additive plays a critical role in...

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Veröffentlicht in:Chemistry : a European journal 2013-12, Vol.19 (50), p.16880-16886
Hauptverfasser: Kou, Xuezhen, Zhao, Mengdi, Qiao, Xixue, Zhu, Yamin, Tong, Xiaofeng, Shen, Zengming
Format: Artikel
Sprache:eng
Schlagworte:
Acetonitrile
Additives
Bonding
catalysis
Cleavage
Copper
cyanation
disilane
Inert
Nitriles
Pastes
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Zusammenfassung:Cut and paste! A Cu‐catalyzed aromatic CH cyanation with acetonitrile as the nitrile source by CCN cleavage has been developed (see scheme; TMEDA=N,N,N′,N′‐tetramethylethylenediamine). The reaction is catalytic in copper, and it is found that using (Me3Si)2 as an additive plays a critical role in promoting CCN cleavage and enhancing the reaction rate.
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201303637