Iridium(III)-Catalyzed CH Amidation of Arylphosphoryls Leading to a P-Stereogenic Center

Direct CH amidation of arylphosphoryl compounds has been developed by using an IrIII catalyst system under mild conditions. A wide range of substrates could be employed with high functional‐group tolerance. This procedure was successfully applied for the first time to the asymmetric reaction giving rise to a P‐chirogenic center with a high diastereomeric ratio of up to 19:1 (90 % de). A road to­ P‐chirality: A cationic [IrIII(Cp*)] complex catalyzes the direct CH amidation of diarylphosphorus compounds bearing a chiral auxiliary to allow for a straightforward route to optically pure P‐chiral compounds (see scheme; Cp*=1,2,3,4,5‐pentamethylcyclopentadiene).