Enantioselective Construction of Spirooxindole Derivatives through [3+2] Annulation Catalyzed by a Bisthiourea as a Multiple-Hydrogen-Bond Donor

Anything between ureas? Spiro[isoxazolidine‐3,3′‐oxindole]s have been constructed by employing methyleneindolinones and nitrones as the starting materials through [3+2] annulation catalyzed by a bisthiourea. Products with three contiguous stereocenters, including one spiroquaternary stereocenter, are obtained in good yields with excellent enantio‐ and diastereoselectivity. The bisthiourea catalyst acts as a multiple‐hydrogen‐bond donor to simultaneously activate both substrates.