Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles
Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐L‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL an...
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| Veröffentlicht in: | Chemistry : a European journal 2013-08, Vol.19 (34), p.11167-11171 |
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| container_end_page | 11171 |
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| container_issue | 34 |
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| container_title | Chemistry : a European journal |
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| creator | Mas, Núria Galiana, Irene Mondragón, Laura Aznar, Elena Climent, Estela Cabedo, Nuria Sancenón, Félix Murguía, José Ramón Martínez-Máñez, Ramón Marcos, María D. Amorós, Pedro |
| description | Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐L‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated. |
| doi_str_mv | 10.1002/chem.201302170 |
| format | Article |
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A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.</description><identifier>ISSN: 0947-6539</identifier><identifier>EISSN: 1521-3765</identifier><identifier>DOI: 10.1002/chem.201302170</identifier><identifier>PMID: 23839913</identifier><identifier>CODEN: CEUJED</identifier><language>eng</language><publisher>Weinheim: WILEY-VCH Verlag</publisher><subject>Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Antiinfectives and antibacterials ; Bacteria ; Capping ; Drug Carriers - chemistry ; Drug Carriers - pharmacology ; Drugs ; Effectiveness ; gated materials ; Gram-Negative Bacteria - drug effects ; mesoporous materials ; Microbial Sensitivity Tests ; Nanoparticles ; Nanoparticles - chemistry ; Nanostructure ; Polylysine - chemistry ; Porosity ; Silicon Dioxide - chemistry ; Vancomycin ; Vancomycin - chemistry ; ε-poly-L-lysine</subject><ispartof>Chemistry : a European journal, 2013-08, Vol.19 (34), p.11167-11171</ispartof><rights>Copyright © 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5140-9fa6940d41c0aa58524009be1623fd6197e7b3c23971edbc527a6d465c0b0583</citedby><cites>FETCH-LOGICAL-c5140-9fa6940d41c0aa58524009be1623fd6197e7b3c23971edbc527a6d465c0b0583</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fchem.201302170$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fchem.201302170$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23839913$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mas, Núria</creatorcontrib><creatorcontrib>Galiana, Irene</creatorcontrib><creatorcontrib>Mondragón, Laura</creatorcontrib><creatorcontrib>Aznar, Elena</creatorcontrib><creatorcontrib>Climent, Estela</creatorcontrib><creatorcontrib>Cabedo, Nuria</creatorcontrib><creatorcontrib>Sancenón, Félix</creatorcontrib><creatorcontrib>Murguía, José Ramón</creatorcontrib><creatorcontrib>Martínez-Máñez, Ramón</creatorcontrib><creatorcontrib>Marcos, María D.</creatorcontrib><creatorcontrib>Amorós, Pedro</creatorcontrib><title>Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles</title><title>Chemistry : a European journal</title><addtitle>Chem. Eur. J</addtitle><description>Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐L‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.</description><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Antiinfectives and antibacterials</subject><subject>Bacteria</subject><subject>Capping</subject><subject>Drug Carriers - chemistry</subject><subject>Drug Carriers - pharmacology</subject><subject>Drugs</subject><subject>Effectiveness</subject><subject>gated materials</subject><subject>Gram-Negative Bacteria - drug effects</subject><subject>mesoporous materials</subject><subject>Microbial Sensitivity Tests</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanostructure</subject><subject>Polylysine - chemistry</subject><subject>Porosity</subject><subject>Silicon Dioxide - chemistry</subject><subject>Vancomycin</subject><subject>Vancomycin - chemistry</subject><subject>ε-poly-L-lysine</subject><issn>0947-6539</issn><issn>1521-3765</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9v0zAYhi3ExLrBlSOyxIVLOv92fexKtzKt48AQR8txnNUjtTM7gfW_J1G3CnEZJ0ufnvfR9_kF4D1GU4wQObMbt50ShCkiWKJXYII5wQWVgr8GE6SYLASn6hic5HyPEFKC0jfgmNAZVQrTCWiXYWOCdRVc1rW3xu6gCRU8T9FULvhwB2MN56HzpbGdS940cG47H8M4_5z6uwx_eQO7jYPfsxuHC9O2g27tcmxjin2GNybE1qTO28blt-CoNk12757eU3B7sbxdrIrrr5dfFvPrwnLMUKFqIxRDFcMWGcNnnLBh-9JhQWhdCaykkyW1hCqJXVVaTqQRFRPcohLxGT0Fn_baNsWH3uVOb322rmlMcMNOGks5Q4wQxV9GGVWESsXIf6CEUTL-7oB-_Ae9j30Kw8kjNdyCqVADNd1TNsWck6t1m_zWpJ3GSI8F67FgfSh4CHx40vbl1lUH_LnRAVB74Ldv3O4FnV6sluu_5cU-63PnHg9Zk35qIank-sfNpV7jC3K--nalEf0Dr6e-iQ</recordid><startdate>20130819</startdate><enddate>20130819</enddate><creator>Mas, Núria</creator><creator>Galiana, Irene</creator><creator>Mondragón, Laura</creator><creator>Aznar, Elena</creator><creator>Climent, Estela</creator><creator>Cabedo, Nuria</creator><creator>Sancenón, Félix</creator><creator>Murguía, José Ramón</creator><creator>Martínez-Máñez, Ramón</creator><creator>Marcos, María D.</creator><creator>Amorós, Pedro</creator><general>WILEY-VCH Verlag</general><general>WILEY‐VCH Verlag</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>K9.</scope><scope>7X8</scope><scope>7QL</scope><scope>7T7</scope><scope>C1K</scope><scope>FR3</scope><scope>P64</scope></search><sort><creationdate>20130819</creationdate><title>Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles</title><author>Mas, Núria ; Galiana, Irene ; Mondragón, Laura ; Aznar, Elena ; Climent, Estela ; Cabedo, Nuria ; Sancenón, Félix ; Murguía, José Ramón ; Martínez-Máñez, Ramón ; Marcos, María D. ; Amorós, Pedro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5140-9fa6940d41c0aa58524009be1623fd6197e7b3c23971edbc527a6d465c0b0583</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Antiinfectives and antibacterials</topic><topic>Bacteria</topic><topic>Capping</topic><topic>Drug Carriers - chemistry</topic><topic>Drug Carriers - pharmacology</topic><topic>Drugs</topic><topic>Effectiveness</topic><topic>gated materials</topic><topic>Gram-Negative Bacteria - drug effects</topic><topic>mesoporous materials</topic><topic>Microbial Sensitivity Tests</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanostructure</topic><topic>Polylysine - chemistry</topic><topic>Porosity</topic><topic>Silicon Dioxide - chemistry</topic><topic>Vancomycin</topic><topic>Vancomycin - chemistry</topic><topic>ε-poly-L-lysine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mas, Núria</creatorcontrib><creatorcontrib>Galiana, Irene</creatorcontrib><creatorcontrib>Mondragón, Laura</creatorcontrib><creatorcontrib>Aznar, Elena</creatorcontrib><creatorcontrib>Climent, Estela</creatorcontrib><creatorcontrib>Cabedo, Nuria</creatorcontrib><creatorcontrib>Sancenón, Félix</creatorcontrib><creatorcontrib>Murguía, José Ramón</creatorcontrib><creatorcontrib>Martínez-Máñez, Ramón</creatorcontrib><creatorcontrib>Marcos, María D.</creatorcontrib><creatorcontrib>Amorós, Pedro</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Chemistry : a European journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mas, Núria</au><au>Galiana, Irene</au><au>Mondragón, Laura</au><au>Aznar, Elena</au><au>Climent, Estela</au><au>Cabedo, Nuria</au><au>Sancenón, Félix</au><au>Murguía, José Ramón</au><au>Martínez-Máñez, Ramón</au><au>Marcos, María D.</au><au>Amorós, Pedro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles</atitle><jtitle>Chemistry : a European journal</jtitle><addtitle>Chem. 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| fulltext | fulltext |
| identifier | ISSN: 0947-6539 |
| ispartof | Chemistry : a European journal, 2013-08, Vol.19 (34), p.11167-11171 |
| issn | 0947-6539 1521-3765 |
| language | eng |
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| source | MEDLINE; Wiley Online Library |
| subjects | Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Bacteria Capping Drug Carriers - chemistry Drug Carriers - pharmacology Drugs Effectiveness gated materials Gram-Negative Bacteria - drug effects mesoporous materials Microbial Sensitivity Tests Nanoparticles Nanoparticles - chemistry Nanostructure Polylysine - chemistry Porosity Silicon Dioxide - chemistry Vancomycin Vancomycin - chemistry ε-poly-L-lysine |
| title | Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles |
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