Enhanced Efficacy and Broadening of Antibacterial Action of Drugs via the Use of Capped Mesoporous Nanoparticles

Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐L‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL an...

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Veröffentlicht in:	Chemistry : a European journal 2013-08, Vol.19 (34), p.11167-11171
Hauptverfasser:	Mas, Núria, Galiana, Irene, Mondragón, Laura, Aznar, Elena, Climent, Estela, Cabedo, Nuria, Sancenón, Félix, Murguía, José Ramón, Martínez-Máñez, Ramón, Marcos, María D., Amorós, Pedro
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antiinfectives and antibacterials Bacteria Capping Drug Carriers - chemistry Drug Carriers - pharmacology Drugs Effectiveness gated materials Gram-Negative Bacteria - drug effects mesoporous materials Microbial Sensitivity Tests Nanoparticles Nanoparticles - chemistry Nanostructure Polylysine - chemistry Porosity Silicon Dioxide - chemistry Vancomycin Vancomycin - chemistry ε-poly-L-lysine
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Zusammenfassung:	Bug busters: A novel nanodevice consisting of mesoporous nanoparticles loaded with vancomycin and capped with ε‐poly‐L‐lysine (ε‐PL) was prepared and its interaction with different Gram‐negative bacteria studied (see figure). A remarkable improvement in the efficacy of the antimicrobial drug ε‐PL and a broadening of the antimicrobial spectrum of vancomycin is demonstrated.
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201302170