Programmable Downregulation of Enzyme Activity Using a Fever and NIR-Responsive Molecularly Imprinted Nanocomposite

A fever and NIR‐responsive molecularly imprinted nanocomposite is designed for programmable downregulation of enzyme activity. The target enzyme can be captured specifically and its activity can be downregulated only when body temperature increases abnormally. Upon NIR irradiation, the temperature o...

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Veröffentlicht in:	Small (Weinheim an der Bergstrasse, Germany) Germany), 2015-12, Vol.11 (46), p.6172-6178
Hauptverfasser:	Zhang, Zhijun, Wang, Zhenzhen, Wang, Faming, Ren, Jinsong, Qu, Xiaogang
Format:	Artikel
Sprache:	eng
Schlagworte:	Body temperature Down-Regulation Enzyme activity enzyme activity regulation Enzymes Fever Fever - pathology Hydrodynamics Hydrolysis Irradiation molecular imprinting Molecular Imprinting - methods Nanocomposites Nanocomposites - chemistry Nanocomposites - ultrastructure Nanotechnology NIR-responsive photothermal Spectrometry, Fluorescence Spectroscopy, Near-Infrared Temperature trypsin Trypsin - metabolism trypsin, nanocomposites
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Beschreibung
Zusammenfassung:	A fever and NIR‐responsive molecularly imprinted nanocomposite is designed for programmable downregulation of enzyme activity. The target enzyme can be captured specifically and its activity can be downregulated only when body temperature increases abnormally. Upon NIR irradiation, the temperature of the destination region can increase accordingly inducing a further decrease in the enzyme activity.
ISSN:	1613-6810 1613-6829
DOI:	10.1002/smll.201502071