Opposing Influences of Ruffling and Doming Deformation on the 4-N Cavity Size of Porphyrin Macrocycles: The Role of Heme Deformations Revealed

Opposing Influences of Ruffling and Doming Deformation on the 4-N Cavity Size of Porphyrin Macrocycles: The Role of Heme Deformations Revealed

Ruffle‐ and dome‐type porphyrins were developed as model systems to investigate the role of deformation mode and degree of distortion in heme. Their crystal structures revealed that as the degree of distortion increases, cavity size can be contracted in the ruffle mode and expanded in the dome mode,...

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Veröffentlicht in:Chemistry : a European journal 2012-06, Vol.18 (25), p.7675-7679
Hauptverfasser: Zhou, Zaichun, Shen, Min, Cao, Chenzhong, Liu, Qiuhua, Yan, Ziqiang
Format: Artikel
Sprache:eng
Schlagworte:
biomimetic synthesis
Chemistry
Crystal structure
Crystallography, X-Ray
Deformation
Distortion
Domes
Heme - chemistry
heme proteins
Hemeproteins - chemistry
Holes
macrocycles
Macrocyclic compounds
Metal ions
metalloenzymes
Models, Molecular
Molecular Structure
porphyrinoids
Porphyrins
Porphyrins - chemistry
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Zusammenfassung:Ruffle‐ and dome‐type porphyrins were developed as model systems to investigate the role of deformation mode and degree of distortion in heme. Their crystal structures revealed that as the degree of distortion increases, cavity size can be contracted in the ruffle mode and expanded in the dome mode, and the size of cavity can exceed the limit of free metal ions from the fourth period (see scheme).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201200722