A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad Actors

A Longitudinal Study of Alkaloid Synthesis Reveals Functional Group Interconversions as Bad Actors

The results of a longitudinal study of alkaloid synthesis that involved five specific approaches are presented. Chemist Albert Ladenburg reduced an unsaturated heteroaromatic molecule to produce a stereogenic, saturated piperidine. The study revealed functional group interconversions as bad actors i...

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Veröffentlicht in:Chemical reviews 2015-09, Vol.115 (17), p.9465-9531
Hauptverfasser: Crossley, Steven W. M, Shenvi, Ryan A
Format: Artikel
Sprache:eng
Schlagworte:
Alkaloids
Alkaloids - chemical synthesis
Chemical engineering
Chemical synthesis
Chemistry Techniques, Synthetic - methods
Chemistry Techniques, Synthetic - trends
Chemists
Correlation analysis
Crystallization
Functional groups
Piperidine
Synthesis
Unsaturated
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Zusammenfassung:The results of a longitudinal study of alkaloid synthesis that involved five specific approaches are presented. Chemist Albert Ladenburg reduced an unsaturated heteroaromatic molecule to produce a stereogenic, saturated piperidine. The study revealed functional group interconversions as bad actors in the process.
ISSN:0009-2665
1520-6890
DOI:10.1021/acs.chemrev.5b00154