A Machine-Assisted Flow Synthesis of SR48692: A Probe for the Investigation of Neurotensin Receptor-1

Here we report the direct comparison of a conventional batch mode synthesis of Meclinertant (SR48692, 1), a neurotensin receptor‐1 antagonist, with its machine‐assisted flow chemistry alternative. By using these enabling tools, combined with solid‐supported reagents and scavengers, many process advantages were observed. Care, however, must be taken not to convert these techniques into expensive solutions to problems that do not exist. Flow and pharmaceuticals? An investigation into whether machine‐assisted technologies can be of true help in the multistep synthesis of a potent neurotensin receptor‐1 probe, Meclinertant (SR48692; see structure), is reported.