Asymmetric Mannich Reaction of [alpha]-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

Asymmetric Mannich Reaction of [alpha]-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α-keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc = tert-butoxycarbonyl, TMS...

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Veröffentlicht in:Chemistry : a European journal 2013-06, Vol.19 (24), p.7678-7681
Hauptverfasser: Hayashi, Yujiro, Sakamoto, Daisuke, Shomura, Hiroki, Hashizume, Daisuke
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Asymmetry
Catalysis
Catalysts
Chemical reactions
Chemistry
Ethers
Imines
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Beschreibung
Zusammenfassung:Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α-keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc = tert-butoxycarbonyl, TMS = trimethylsilyl).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201300513