Forensic application of microRNA-706 as a biomarker for drowning pattern identification

Highlights • Forensic application of microRNA to identify the manner of death is available. • microRNA-706 is differentially expressed between freshwater and saltwater drowning brain. • microRNA-706 is specifically expressed in hippocampal neurons. • HCN1 gene is targeted by microRNA-706 and differe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Forensic science international 2015-10, Vol.255, p.96-101
Hauptverfasser:	Yu, SeonYoung, Na, Joo-Young, Lee, Young-Jik, Kim, Kyung-Tae, Park, Jong-Tae, Kim, Hyung-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bioinformatics Biomarker Biomarkers Death identification Down-Regulation Drowning Drowning - diagnosis Drownings Forensic Forensic engineering Forensic Genetics Forensic science Forensic sciences Fresh Water Freshwaters Gene expression Genetic Markers Hippocampus - metabolism Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Male Mice, Inbred ICR microRNA MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism Models, Animal Neurons Neurons - metabolism Oceans and Seas Pathology Polymerase Chain Reaction Potassium Channels - genetics Potassium Channels - metabolism Ribonucleic acids RNA, Messenger - metabolism Rodents Up-Regulation
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Highlights • Forensic application of microRNA to identify the manner of death is available. • microRNA-706 is differentially expressed between freshwater and saltwater drowning brain. • microRNA-706 is specifically expressed in hippocampal neurons. • HCN1 gene is targeted by microRNA-706 and differentially expressed between freshwater and saltwater drowning brain.
ISSN:	0379-0738 1872-6283
DOI:	10.1016/j.forsciint.2015.06.011