A Survey of Sulfide Ligands for Allylic CH Oxidations of Terminal Olefins

A Survey of Sulfide Ligands for Allylic CH Oxidations of Terminal Olefins

Perfect to a THT! Screening a diverse library of thioether ligands led to the discovery of tetrahydrothiophene (THT) as a highly reactive and selective ligand for Pd‐catalyzed allylic CH oxidation reactions (see scheme). This novel ligand system provides some of the highest reported yields for the...

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Veröffentlicht in:Chemistry : a European journal 2013-08, Vol.19 (34), p.11153-11157
Hauptverfasser: Le, Chi "Chip", Kunchithapatham, Kamala, Henderson, William H., Check, Christopher T., Stambuli, James P.
Format: Artikel
Sprache:eng
Schlagworte:
Activation
allylic compounds
Formations
ligand effects
Ligands
Olefins
Oxidation
Screening
Sulfides
sulfur heterocycles
Terminals
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Beschreibung
Zusammenfassung:Perfect to a THT! Screening a diverse library of thioether ligands led to the discovery of tetrahydrothiophene (THT) as a highly reactive and selective ligand for Pd‐catalyzed allylic CH oxidation reactions (see scheme). This novel ligand system provides some of the highest reported yields for the formation of (E)‐linear allylic acetates through allylic CH activation chemistry (BQ = 1,4‐benzoquinone).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201301787