Genotoxic effects of camphorquinone and DMT on human oral and intestinal cells
Highlights • Camphorquinone (CQ) induced DNA lesions in OKF6/TERT2 and Caco-2 cells. • This DNA damage is mainly caused by the generation of 8-oxoguanine. • The antioxidant glutathione prevented CQ-associated DNA damage in Caco-2 cells. • Recovery following CQ-treatment significantly reduced DNA dam...
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| Veröffentlicht in: | Dental materials 2015-10, Vol.31 (10), p.1159-1168 |
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| container_title | Dental materials |
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| creator | Wessels, Miriam Rimkus, Julia Leyhausen, Gabriele Volk, Joachim Geurtsen, Werner |
| description | Highlights • Camphorquinone (CQ) induced DNA lesions in OKF6/TERT2 and Caco-2 cells. • This DNA damage is mainly caused by the generation of 8-oxoguanine. • The antioxidant glutathione prevented CQ-associated DNA damage in Caco-2 cells. • Recovery following CQ-treatment significantly reduced DNA damage in Caco-2 cells. |
| doi_str_mv | 10.1016/j.dental.2015.06.007 |
| format | Article |
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| ispartof | Dental materials, 2015-10, Vol.31 (10), p.1159-1168 |
| issn | 0109-5641 1879-0097 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | 8-Oxoguanine Advanced Basic Science Antioxidants - pharmacology Bioassay Caco-2 Cells - drug effects Camphor - analogs & derivatives Camphor - toxicity Camphorquinone Comet Assay Damage Damage detection Dental materials Dentistry Deoxyribonucleic acid DNA Damage Genotoxicity Glutathione - pharmacology Guanine - analogs & derivatives Guanine - toxicity Humans In Vitro Techniques Keratinocytes - drug effects Mouth Mucosa - cytology Oxidative Stress Photoinitiators Reactive oxygen species Reactive Oxygen Species - toxicity Recovery Toluidines - toxicity |
| title | Genotoxic effects of camphorquinone and DMT on human oral and intestinal cells |
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