Genotoxic effects of camphorquinone and DMT on human oral and intestinal cells

Highlights • Camphorquinone (CQ) induced DNA lesions in OKF6/TERT2 and Caco-2 cells. • This DNA damage is mainly caused by the generation of 8-oxoguanine. • The antioxidant glutathione prevented CQ-associated DNA damage in Caco-2 cells. • Recovery following CQ-treatment significantly reduced DNA dam...

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Veröffentlicht in:	Dental materials 2015-10, Vol.31 (10), p.1159-1168
Hauptverfasser:	Wessels, Miriam, Rimkus, Julia, Leyhausen, Gabriele, Volk, Joachim, Geurtsen, Werner
Format:	Artikel
Sprache:	eng
Schlagworte:	8-Oxoguanine Advanced Basic Science Antioxidants - pharmacology Bioassay Caco-2 Cells - drug effects Camphor - analogs & derivatives Camphor - toxicity Camphorquinone Comet Assay Damage Damage detection Dental materials Dentistry Deoxyribonucleic acid DNA Damage Genotoxicity Glutathione - pharmacology Guanine - analogs & derivatives Guanine - toxicity Humans In Vitro Techniques Keratinocytes - drug effects Mouth Mucosa - cytology Oxidative Stress Photoinitiators Reactive oxygen species Reactive Oxygen Species - toxicity Recovery Toluidines - toxicity
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Zusammenfassung:	Highlights • Camphorquinone (CQ) induced DNA lesions in OKF6/TERT2 and Caco-2 cells. • This DNA damage is mainly caused by the generation of 8-oxoguanine. • The antioxidant glutathione prevented CQ-associated DNA damage in Caco-2 cells. • Recovery following CQ-treatment significantly reduced DNA damage in Caco-2 cells.
ISSN:	0109-5641 1879-0097
DOI:	10.1016/j.dental.2015.06.007