tert-Butyl Nitrite Mediated Regiospecific Nitration of (E)-Azoarenes through Palladium-Catalyzed Directed CH Activation

An efficient protocol for the Pd‐catalyzed regiospecific ortho‐nitration of (E)‐azoarenes has been achieved for the first time using tBuONO as a nitrating agent under atmospheric oxygen. A series of both symmetrical and unsymmetrical azoarenes were nitrated efficiently by this procedure providing excellent chemo‐ and regioselectivity and compatibility with a broad array of functional groups. Well placed: An efficient protocol for the Pd‐catalyzed regiospecific ortho‐nitration of (E)‐azoarenes has been achieved by using tBuONO as a nitrating agent under atmospheric oxygen. A series of both symmetrical and unsymmetrical azoarenes were nitrated efficiently by this procedure, providing excellent chemo‐ and regioselectivity and compatibility with a broad array of functional groups.