Enantioselective Construction of Functionalized Tetrahydrocarbazoles Enabled by Asymmetric Relay Catalysis of Gold Complex and Chiral Brønsted Acid

Enantioselective Construction of Functionalized Tetrahydrocarbazoles Enabled by Asymmetric Relay Catalysis of Gold Complex and Chiral Brønsted Acid

An intramolecular hydroamination/Michael addition cascade is realized using a combination of gold­(I) complex and chiral BINOL–phosphoric acid, affording fused-tetrahydrocarbazole scaffolds in excellent yields and high enantioselectivities.

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Veröffentlicht in:Organic letters 2016-04, Vol.18 (7), p.1506-1509
Hauptverfasser: Zhao, Feng, Li, Nan, Zhu, Yi-Fan, Han, Zhi-Yong
Format: Artikel
Sprache:eng
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Zusammenfassung:An intramolecular hydroamination/Michael addition cascade is realized using a combination of gold­(I) complex and chiral BINOL–phosphoric acid, affording fused-tetrahydrocarbazole scaffolds in excellent yields and high enantioselectivities.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.6b00012