Changes in intrafollicular concentrations of free IGF-1, activin A, inhibin A, VEGF, estradiol, and prolactin before ovulation in mares
Changes in intrafollicular growth factors and hormones were evaluated in vivo in postdeviation and impending ovulation follicles. Mares (n = 30) were randomly assigned to five experimental groups based on target diameters of 25, 30, 35, 40 mm, and impending signs of ovulation. Furthermore, data belo...
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| Veröffentlicht in: | Theriogenology 2016-05, Vol.85 (8), p.1491-1498 |
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| creator | Bashir, S.T. Ishak, G.M. Gastal, M.O. Roser, J.F. Gastal, E.L. |
| description | Changes in intrafollicular growth factors and hormones were evaluated in vivo in postdeviation and impending ovulation follicles. Mares (n = 30) were randomly assigned to five experimental groups based on target diameters of 25, 30, 35, 40 mm, and impending signs of ovulation. Furthermore, data belonging to two or more proximal diameter groups that were not different were combined and regrouped for each factor separately. Follicular fluid-free insulin-like growth factor 1 was highest (P 0.05) among groups. Additionally, follicular fluid activin A tended (P |
| doi_str_mv | 10.1016/j.theriogenology.2016.01.013 |
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Mares (n = 30) were randomly assigned to five experimental groups based on target diameters of 25, 30, 35, 40 mm, and impending signs of ovulation. Furthermore, data belonging to two or more proximal diameter groups that were not different were combined and regrouped for each factor separately. Follicular fluid-free insulin-like growth factor 1 was highest (P < 0.003) in 35-mm follicles, followed by the 40-mm and impending ovulation follicle group, and the 25- to 30-mm follicle group. However, concentrations of insulin-like growth factor binding protein 2 in follicular fluid did not differ (P > 0.05) among groups. Additionally, follicular fluid activin A tended (P < 0.06) to be higher in impending ovulation follicles when compared with the 25- to 40-mm follicle group. Concentrations of intrafollicular estradiol were higher (P < 0.0001) in 40-mm and impending ovulation follicles than in the other follicle groups. Follicular fluid concentrations of inhibin A and vascular endothelial growth factor were lower (P < 0.05) in the 40-mm and the impending ovulation follicle group when compared with the 25- to 35-mm follicle group. Systemic and intrafollicular prolactin levels were lower (P < 0.05) in the impending ovulation group when compared with the 25- to 40-mm follicle group. Prolactin concentrations were higher (P < 0.05) in the follicular fluid than in the plasma. The novel findings of this study, a decrease in intrafollicular-free insulin-like growth factor 1, inhibin A, vascular endothelial growth factor, and prolactin during the final stages of follicular growth, document for the first time the occurrence of dynamic changes among intrafollicular factors and hormones during the stages of follicle dominance and as ovulation approaches.]]></description><identifier>ISSN: 0093-691X</identifier><identifier>EISSN: 1879-3231</identifier><identifier>DOI: 10.1016/j.theriogenology.2016.01.013</identifier><identifier>PMID: 26895618</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Activins - metabolism ; Animals ; Estradiol - metabolism ; Female ; Follicle deviation ; Follicular Fluid - metabolism ; Hormone ; Horses - metabolism ; Impending ovulation ; Inhibins - metabolism ; Insulin-Like Growth Factor I - metabolism ; Intercellular Signaling Peptides and Proteins - metabolism ; Intrafollicular growth factor ; Mare ; Ovarian Follicle - growth & development ; Ovarian Follicle - metabolism ; Ovulation - metabolism ; Prolactin - metabolism ; Random Allocation ; Vascular Endothelial Growth Factor A - metabolism</subject><ispartof>Theriogenology, 2016-05, Vol.85 (8), p.1491-1498</ispartof><rights>2016 Elsevier Inc.</rights><rights>Copyright © 2016 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c452t-e00d92df4fa122d90d5d78598c482258ddb47dfd03d1505f2a7d58b5aa2534783</citedby><cites>FETCH-LOGICAL-c452t-e00d92df4fa122d90d5d78598c482258ddb47dfd03d1505f2a7d58b5aa2534783</cites><orcidid>0000-0002-8855-6980 ; 0000-0003-3448-0578</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0093691X16000145$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26895618$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bashir, S.T.</creatorcontrib><creatorcontrib>Ishak, G.M.</creatorcontrib><creatorcontrib>Gastal, M.O.</creatorcontrib><creatorcontrib>Roser, J.F.</creatorcontrib><creatorcontrib>Gastal, E.L.</creatorcontrib><title>Changes in intrafollicular concentrations of free IGF-1, activin A, inhibin A, VEGF, estradiol, and prolactin before ovulation in mares</title><title>Theriogenology</title><addtitle>Theriogenology</addtitle><description><![CDATA[Changes in intrafollicular growth factors and hormones were evaluated in vivo in postdeviation and impending ovulation follicles. Mares (n = 30) were randomly assigned to five experimental groups based on target diameters of 25, 30, 35, 40 mm, and impending signs of ovulation. Furthermore, data belonging to two or more proximal diameter groups that were not different were combined and regrouped for each factor separately. Follicular fluid-free insulin-like growth factor 1 was highest (P < 0.003) in 35-mm follicles, followed by the 40-mm and impending ovulation follicle group, and the 25- to 30-mm follicle group. However, concentrations of insulin-like growth factor binding protein 2 in follicular fluid did not differ (P > 0.05) among groups. Additionally, follicular fluid activin A tended (P < 0.06) to be higher in impending ovulation follicles when compared with the 25- to 40-mm follicle group. Concentrations of intrafollicular estradiol were higher (P < 0.0001) in 40-mm and impending ovulation follicles than in the other follicle groups. Follicular fluid concentrations of inhibin A and vascular endothelial growth factor were lower (P < 0.05) in the 40-mm and the impending ovulation follicle group when compared with the 25- to 35-mm follicle group. Systemic and intrafollicular prolactin levels were lower (P < 0.05) in the impending ovulation group when compared with the 25- to 40-mm follicle group. Prolactin concentrations were higher (P < 0.05) in the follicular fluid than in the plasma. The novel findings of this study, a decrease in intrafollicular-free insulin-like growth factor 1, inhibin A, vascular endothelial growth factor, and prolactin during the final stages of follicular growth, document for the first time the occurrence of dynamic changes among intrafollicular factors and hormones during the stages of follicle dominance and as ovulation approaches.]]></description><subject>Activins - metabolism</subject><subject>Animals</subject><subject>Estradiol - metabolism</subject><subject>Female</subject><subject>Follicle deviation</subject><subject>Follicular Fluid - metabolism</subject><subject>Hormone</subject><subject>Horses - metabolism</subject><subject>Impending ovulation</subject><subject>Inhibins - metabolism</subject><subject>Insulin-Like Growth Factor I - metabolism</subject><subject>Intercellular Signaling Peptides and Proteins - metabolism</subject><subject>Intrafollicular growth factor</subject><subject>Mare</subject><subject>Ovarian Follicle - growth & development</subject><subject>Ovarian Follicle - metabolism</subject><subject>Ovulation - metabolism</subject><subject>Prolactin - metabolism</subject><subject>Random Allocation</subject><subject>Vascular Endothelial Growth Factor A - metabolism</subject><issn>0093-691X</issn><issn>1879-3231</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU1rGzEUFCWlcdP-haJDDzl4XX2sdrWQSzCxEwj00pbehFZ6smXkVSKtDfkF-dvV4jSQW9CAxGPmzdMbhL5TsqCENj92i3ELyccNDDHEzdOCleqC0AL-Ac2obLuKM07P0IyQjldNR_-eo8857wghvGnoJ3TOGtmJhsoZel5u9bCBjP1QMCbtYgjeHIJO2MTBwFQbfRwyjg67BIDv1quKzrE2oz8W1fW8CLe-Pz3_3KxXcwy5qKyPodAGix9SDBN9wD24mADHYzGYuk62e50gf0EfnQ4Zvr7cF-j36ubX8ra6_7m-W17fV6YWbKyAENsx62qnKWO2I1bYVopOmloyJqS1fd1aZwm3VBDhmG6tkL3Qmglet5JfoMtT3zLT46HMqfY-GwhBDxAPWdG2bbvpkEK9OlFNijkncOoh-TLsk6JETVGonXobhZqiUIQW8CL_9uJ06PdgX8X_d18IqxMByn-PHpLKxkNZufUJzKhs9O9z-gfxyqP3</recordid><startdate>201605</startdate><enddate>201605</enddate><creator>Bashir, S.T.</creator><creator>Ishak, G.M.</creator><creator>Gastal, M.O.</creator><creator>Roser, J.F.</creator><creator>Gastal, E.L.</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-8855-6980</orcidid><orcidid>https://orcid.org/0000-0003-3448-0578</orcidid></search><sort><creationdate>201605</creationdate><title>Changes in intrafollicular concentrations of free IGF-1, activin A, inhibin A, VEGF, estradiol, and prolactin before ovulation in mares</title><author>Bashir, S.T. ; Ishak, G.M. ; Gastal, M.O. ; Roser, J.F. ; Gastal, E.L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c452t-e00d92df4fa122d90d5d78598c482258ddb47dfd03d1505f2a7d58b5aa2534783</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Activins - metabolism</topic><topic>Animals</topic><topic>Estradiol - metabolism</topic><topic>Female</topic><topic>Follicle deviation</topic><topic>Follicular Fluid - metabolism</topic><topic>Hormone</topic><topic>Horses - metabolism</topic><topic>Impending ovulation</topic><topic>Inhibins - metabolism</topic><topic>Insulin-Like Growth Factor I - metabolism</topic><topic>Intercellular Signaling Peptides and Proteins - metabolism</topic><topic>Intrafollicular growth factor</topic><topic>Mare</topic><topic>Ovarian Follicle - growth & development</topic><topic>Ovarian Follicle - metabolism</topic><topic>Ovulation - metabolism</topic><topic>Prolactin - metabolism</topic><topic>Random Allocation</topic><topic>Vascular Endothelial Growth Factor A - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bashir, S.T.</creatorcontrib><creatorcontrib>Ishak, G.M.</creatorcontrib><creatorcontrib>Gastal, M.O.</creatorcontrib><creatorcontrib>Roser, J.F.</creatorcontrib><creatorcontrib>Gastal, E.L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Theriogenology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bashir, S.T.</au><au>Ishak, G.M.</au><au>Gastal, M.O.</au><au>Roser, J.F.</au><au>Gastal, E.L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes in intrafollicular concentrations of free IGF-1, activin A, inhibin A, VEGF, estradiol, and prolactin before ovulation in mares</atitle><jtitle>Theriogenology</jtitle><addtitle>Theriogenology</addtitle><date>2016-05</date><risdate>2016</risdate><volume>85</volume><issue>8</issue><spage>1491</spage><epage>1498</epage><pages>1491-1498</pages><issn>0093-691X</issn><eissn>1879-3231</eissn><abstract><![CDATA[Changes in intrafollicular growth factors and hormones were evaluated in vivo in postdeviation and impending ovulation follicles. Mares (n = 30) were randomly assigned to five experimental groups based on target diameters of 25, 30, 35, 40 mm, and impending signs of ovulation. Furthermore, data belonging to two or more proximal diameter groups that were not different were combined and regrouped for each factor separately. Follicular fluid-free insulin-like growth factor 1 was highest (P < 0.003) in 35-mm follicles, followed by the 40-mm and impending ovulation follicle group, and the 25- to 30-mm follicle group. However, concentrations of insulin-like growth factor binding protein 2 in follicular fluid did not differ (P > 0.05) among groups. Additionally, follicular fluid activin A tended (P < 0.06) to be higher in impending ovulation follicles when compared with the 25- to 40-mm follicle group. Concentrations of intrafollicular estradiol were higher (P < 0.0001) in 40-mm and impending ovulation follicles than in the other follicle groups. Follicular fluid concentrations of inhibin A and vascular endothelial growth factor were lower (P < 0.05) in the 40-mm and the impending ovulation follicle group when compared with the 25- to 35-mm follicle group. Systemic and intrafollicular prolactin levels were lower (P < 0.05) in the impending ovulation group when compared with the 25- to 40-mm follicle group. Prolactin concentrations were higher (P < 0.05) in the follicular fluid than in the plasma. The novel findings of this study, a decrease in intrafollicular-free insulin-like growth factor 1, inhibin A, vascular endothelial growth factor, and prolactin during the final stages of follicular growth, document for the first time the occurrence of dynamic changes among intrafollicular factors and hormones during the stages of follicle dominance and as ovulation approaches.]]></abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>26895618</pmid><doi>10.1016/j.theriogenology.2016.01.013</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-8855-6980</orcidid><orcidid>https://orcid.org/0000-0003-3448-0578</orcidid></addata></record> |
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| ispartof | Theriogenology, 2016-05, Vol.85 (8), p.1491-1498 |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Activins - metabolism Animals Estradiol - metabolism Female Follicle deviation Follicular Fluid - metabolism Hormone Horses - metabolism Impending ovulation Inhibins - metabolism Insulin-Like Growth Factor I - metabolism Intercellular Signaling Peptides and Proteins - metabolism Intrafollicular growth factor Mare Ovarian Follicle - growth & development Ovarian Follicle - metabolism Ovulation - metabolism Prolactin - metabolism Random Allocation Vascular Endothelial Growth Factor A - metabolism |
| title | Changes in intrafollicular concentrations of free IGF-1, activin A, inhibin A, VEGF, estradiol, and prolactin before ovulation in mares |
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