How central is nitric oxide (NO) to the activation of c-fos in spinal neurones following noxious peripheral stimulation in the rat?

Intrathecal application of high doses of NO-donor compounds in the anaesthetised rat was not found to cause any induction of c-fos in spinal neurones. Furthermore, intrathecal injection of a NO-synthase (NOS) blocking drug did not alter the numbers of c-fos positive neurones induced by noxious stimu...

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Veröffentlicht in:	Brain research 2001-01, Vol.888 (1), p.172-175
Hauptverfasser:	Nazli, M., Hismiogullari, E.S., Thippeswamy, T., Morris, R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences c-fos Enzyme Inhibitors - pharmacology Female Fundamental and applied biological sciences. Psychology Male Mustard Plant Neurons - enzymology NG-Nitroarginine Methyl Ester - pharmacology Nitric oxide Nitric Oxide - metabolism Nitric Oxide Synthase - metabolism Nociception Nociceptors - metabolism Noxae Pain Pain - chemically induced Pain - metabolism Peripheral Nerves - physiology Plant Extracts Plant Oils Proto-Oncogene Proteins c-fos - metabolism Rats Rats, Wistar Somesthesis and somesthetic pathways (proprioception, exteroception, nociception) interoception electrolocation. Sensory receptors Spinal cord Spinal Cord - cytology Vertebrates: nervous system and sense organs
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Zusammenfassung:	Intrathecal application of high doses of NO-donor compounds in the anaesthetised rat was not found to cause any induction of c-fos in spinal neurones. Furthermore, intrathecal injection of a NO-synthase (NOS) blocking drug did not alter the numbers of c-fos positive neurones induced by noxious stimulation. Additionally very little colocalization between NOS and c-fos following noxious stimulation was found. Collectively these data give no support for a role for NO in the noxiously evoked induction of c-fos.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/S0006-8993(00)03099-7