Drug resistance does not correlate with resistance to Fas-mediated apoptosis
Recent reports have correlated multidrug resistance (MDR) and P-glycoprotein expression with decreased Fas expression and resistance to Fas-mediated apoptosis. We report the MRP-overexpressing MDR subline CEM/E1000 has the same Fas expression (MFI 74.3±0.7) as the parental CCRF-CEM T-cell leukaemia...
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| Veröffentlicht in: | Leukemia research 2001, Vol.25 (1), p.69-75 |
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| creator | Cullen, Karen V Davey, Ross A Davey, Mary W |
| description | Recent reports have correlated multidrug resistance (MDR) and P-glycoprotein expression with decreased Fas expression and resistance to Fas-mediated apoptosis. We report the MRP-overexpressing MDR subline CEM/E1000 has the same Fas expression (MFI 74.3±0.7) as the parental CCRF-CEM T-cell leukaemia cells (MFI 70.0±3.6;
P>0.05), and that the level of apoptosis induced by anti-Fas antibody or drug was similar in both cell lines. Further the P-glycoprotein-expressing CEM/VLB
100 subline of the CCRF-CEM cells showed increased Fas expression (MFI 114.8±3.6;
P |
| doi_str_mv | 10.1016/S0145-2126(00)00085-0 |
| format | Article |
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100 subline of the CCRF-CEM cells showed increased Fas expression (MFI 114.8±3.6;
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P>0.05), and that the level of apoptosis induced by anti-Fas antibody or drug was similar in both cell lines. Further the P-glycoprotein-expressing CEM/VLB
100 subline of the CCRF-CEM cells showed increased Fas expression (MFI 114.8±3.6;
P<0.001) and no resistance to Fas-mediated apoptosis. This questions the hypothesis that selection of drug resistance results in resistance to Fas-mediated apoptosis, with important implications for the rational use of immunotherapy in the treatment of drug resistant cancer.</description><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - pharmacology</subject><subject>Antineoplastic agents</subject><subject>Antineoplastic Agents - toxicity</subject><subject>Antineoplastic Agents, Phytogenic - toxicity</subject><subject>Apoptosis</subject><subject>Apoptosis - drug effects</subject><subject>Apoptosis - physiology</subject><subject>ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis</subject><subject>ATP-Binding Cassette Transporters - biosynthesis</subject><subject>Biological and medical sciences</subject><subject>Cisplatin - toxicity</subject><subject>Drug Resistance, Multiple - physiology</subject><subject>Drug Resistance, Neoplasm</subject><subject>Etoposide - toxicity</subject><subject>Fas (CD95)</subject><subject>Fas antigen</subject><subject>fas Receptor - biosynthesis</subject><subject>fas Receptor - immunology</subject><subject>fas Receptor - physiology</subject><subject>General aspects</subject><subject>Humans</subject><subject>Immunoglobulin M - immunology</subject><subject>Immunoglobulin M - pharmacology</subject><subject>Leukemia, T-Cell - drug therapy</subject><subject>Leukemia, T-Cell - metabolism</subject><subject>Leukemia, T-Cell - pathology</subject><subject>Medical sciences</subject><subject>Multidrug resistance</subject><subject>Multidrug resistance-associated protein</subject><subject>Multidrug Resistance-Associated Proteins</subject><subject>P-glycoprotein</subject><subject>Pharmacology. 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Drug treatments</topic><topic>Tumor Cells, Cultured</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cullen, Karen V</creatorcontrib><creatorcontrib>Davey, Ross A</creatorcontrib><creatorcontrib>Davey, Mary W</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Leukemia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cullen, Karen V</au><au>Davey, Ross A</au><au>Davey, Mary W</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Drug resistance does not correlate with resistance to Fas-mediated apoptosis</atitle><jtitle>Leukemia research</jtitle><addtitle>Leuk Res</addtitle><date>2001</date><risdate>2001</risdate><volume>25</volume><issue>1</issue><spage>69</spage><epage>75</epage><pages>69-75</pages><issn>0145-2126</issn><eissn>1873-5835</eissn><coden>LEREDD</coden><abstract>Recent reports have correlated multidrug resistance (MDR) and P-glycoprotein expression with decreased Fas expression and resistance to Fas-mediated apoptosis. We report the MRP-overexpressing MDR subline CEM/E1000 has the same Fas expression (MFI 74.3±0.7) as the parental CCRF-CEM T-cell leukaemia cells (MFI 70.0±3.6;
P>0.05), and that the level of apoptosis induced by anti-Fas antibody or drug was similar in both cell lines. Further the P-glycoprotein-expressing CEM/VLB
100 subline of the CCRF-CEM cells showed increased Fas expression (MFI 114.8±3.6;
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antineoplastic agents Antineoplastic Agents - toxicity Antineoplastic Agents, Phytogenic - toxicity Apoptosis Apoptosis - drug effects Apoptosis - physiology ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis ATP-Binding Cassette Transporters - biosynthesis Biological and medical sciences Cisplatin - toxicity Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm Etoposide - toxicity Fas (CD95) Fas antigen fas Receptor - biosynthesis fas Receptor - immunology fas Receptor - physiology General aspects Humans Immunoglobulin M - immunology Immunoglobulin M - pharmacology Leukemia, T-Cell - drug therapy Leukemia, T-Cell - metabolism Leukemia, T-Cell - pathology Medical sciences Multidrug resistance Multidrug resistance-associated protein Multidrug Resistance-Associated Proteins P-glycoprotein Pharmacology. Drug treatments Tumor Cells, Cultured |
| title | Drug resistance does not correlate with resistance to Fas-mediated apoptosis |
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