Drug resistance does not correlate with resistance to Fas-mediated apoptosis

Recent reports have correlated multidrug resistance (MDR) and P-glycoprotein expression with decreased Fas expression and resistance to Fas-mediated apoptosis. We report the MRP-overexpressing MDR subline CEM/E1000 has the same Fas expression (MFI 74.3±0.7) as the parental CCRF-CEM T-cell leukaemia...

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Veröffentlicht in:	Leukemia research 2001, Vol.25 (1), p.69-75
Hauptverfasser:	Cullen, Karen V, Davey, Ross A, Davey, Mary W
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Monoclonal - immunology Antibodies, Monoclonal - pharmacology Antineoplastic agents Antineoplastic Agents - toxicity Antineoplastic Agents, Phytogenic - toxicity Apoptosis Apoptosis - drug effects Apoptosis - physiology ATP Binding Cassette Transporter, Subfamily B, Member 1 - biosynthesis ATP-Binding Cassette Transporters - biosynthesis Biological and medical sciences Cisplatin - toxicity Drug Resistance, Multiple - physiology Drug Resistance, Neoplasm Etoposide - toxicity Fas (CD95) Fas antigen fas Receptor - biosynthesis fas Receptor - immunology fas Receptor - physiology General aspects Humans Immunoglobulin M - immunology Immunoglobulin M - pharmacology Leukemia, T-Cell - drug therapy Leukemia, T-Cell - metabolism Leukemia, T-Cell - pathology Medical sciences Multidrug resistance Multidrug resistance-associated protein Multidrug Resistance-Associated Proteins P-glycoprotein Pharmacology. Drug treatments Tumor Cells, Cultured
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Zusammenfassung:	Recent reports have correlated multidrug resistance (MDR) and P-glycoprotein expression with decreased Fas expression and resistance to Fas-mediated apoptosis. We report the MRP-overexpressing MDR subline CEM/E1000 has the same Fas expression (MFI 74.3±0.7) as the parental CCRF-CEM T-cell leukaemia cells (MFI 70.0±3.6; P>0.05), and that the level of apoptosis induced by anti-Fas antibody or drug was similar in both cell lines. Further the P-glycoprotein-expressing CEM/VLB 100 subline of the CCRF-CEM cells showed increased Fas expression (MFI 114.8±3.6; P
ISSN:	0145-2126 1873-5835
DOI:	10.1016/S0145-2126(00)00085-0