Immune suppression and skin cancer development: regulation by NKT cells

Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing...

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Veröffentlicht in:	Nature immunology 2000-12, Vol.1 (6), p.521-525
Hauptverfasser:	Nghiem, Dat, Ullrich, Stephen E, Moodycliffe, Angus M, Clydesdale, Gavin
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens - administration & dosage Antigens, CD1 - genetics Antigens, CD1 - metabolism Biomedical and Life Sciences Biomedicine Female Hypersensitivity Hypersensitivity, Delayed Immune Tolerance Immunology Infectious Diseases Killer Cells, Natural - immunology Mice Mice, Inbred C3H Mice, Inbred C57BL Mice, Knockout Neoplasms, Radiation-Induced - immunology Skin Neoplasms - immunology Spleen - immunology T-Lymphocyte Subsets - immunology Ultraviolet Rays - adverse effects
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