Immune suppression and skin cancer development: regulation by NKT cells

Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing...

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Veröffentlicht in:Nature immunology 2000-12, Vol.1 (6), p.521-525
Hauptverfasser: Nghiem, Dat, Ullrich, Stephen E, Moodycliffe, Angus M, Clydesdale, Gavin
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Sprache:eng
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Zusammenfassung:Ultraviolet (UV) radiation is carcinogenic and immunosuppressive. UV-induced immune suppression is mediated by antigen-specific T cells, which can transfer suppression to normal recipients. These cells are essential for controlling skin cancer development in the UV-irradiated host and in suppressing other immune responses, such as delayed-type hypersensitivity. Despite their importance in skin cancer development, their exact identity has remained elusive. We show here that natural killer T cells from UV-irradiated donor mice function as suppressor T cells and play a critical role in regulating the growth of UV-induced skin cancers and suppressing adaptive immune responses in vivo .
ISSN:1529-2908
1529-2916
DOI:10.1038/82782