A measles outbreak in a middle school with high vaccination coverage and evidence of prior immunity among cases, Beijing, P.R. China

Highlights • This is the first report from China on measles transmission among persons with evidence of prior immunity. • The risk of measles among individuals with age-appropriate receipt of ≥2 MCV doses was inversely related to length of time since the receipt of the last MCV. • For vaccinated cas...

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Veröffentlicht in:	Vaccine 2016-04, Vol.34 (15), p.1853-1860
Hauptverfasser:	Ma, Rui, Lu, Li, Zhangzhu, Jiazi, Chen, Meng, Yu, Xiali, Wang, Fengshuang, Peng, Xiaoran, Wu, Jiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Age Allergy and Immunology Antibodies, Viral - blood Beijing China - epidemiology Confidence intervals Disease Disease Outbreaks Dormitories Epidemics Female Fever Humans Immunity Immunoglobulin G Immunoglobulins Laboratory tests Male Measles Measles - epidemiology Measles - prevention & control Measles Vaccine - administration & dosage Measles Vaccine - therapeutic use Medical laboratories Middle schools Outbreak Outbreaks Risk Factors Schools Secondary vaccine failure Students Vaccination - statistics & numerical data Vaccines
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Zusammenfassung:	Highlights • This is the first report from China on measles transmission among persons with evidence of prior immunity. • The risk of measles among individuals with age-appropriate receipt of ≥2 MCV doses was inversely related to length of time since the receipt of the last MCV. • For vaccinated cases, IgM testing using serum collected 4–28 days after rash onset and viral testing can avoid false negative IgM tests that can result from testing serum collected 0–3 days after rash onset.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.11.006