Immune response to second vaccination series of hepatitis B virus among booster dose non-responders

Highlights • Out of 1070 children given a booster dose, 103 failed to generate anamnestic response. • 91/103 children received 2nd vaccination series of HBV vaccine. • About 92% of them developed protective immune response (anti HBs ≥ 10 IU). • Vaccination failure was only among children ≥10 years w...

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Veröffentlicht in:	Vaccine 2016-04, Vol.34 (16), p.1904-1908
Hauptverfasser:	Salama, Iman I, Sami, Samia M, Salama, Somaia I, Rabah, Thanaa Mahmoud, El Etreby, Lobna Ahmed, Abdel Hamid, Amany T, Elmosalami, Dalia, El Hariri, Hazem, Said, Zeinab N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Age groups Allergy and Immunology Child Child, Preschool Children & youth Conflicts of interest Egypt Female HBV Hepatitis Hepatitis B - prevention & control Hepatitis B Antibodies - blood Hepatitis B Vaccines - administration & dosage Hepatitis B Vaccines - therapeutic use Hepatitis B virus Humans Immune response Immunity Immunization, Secondary Immunologic Memory Immunology Infant Infections Male Parents & parenting Prospective Studies Rural areas Second vaccination series Vaccination - methods Vaccines Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - therapeutic use Viral infections
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Beschreibung
Zusammenfassung:	Highlights • Out of 1070 children given a booster dose, 103 failed to generate anamnestic response. • 91/103 children received 2nd vaccination series of HBV vaccine. • About 92% of them developed protective immune response (anti HBs ≥ 10 IU). • Vaccination failure was only among children ≥10 years with post-booster undetectable anti-HBs. • High risk children non-responders to a booster dose need HBV revaccination.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.02.050