miR expression profiling at diagnosis predicts relapse in pediatric precursor B-cell acute lymphoblastic leukemia

Our aim was to identify miRNAs that can predict risk of relapse in pediatric patients with acute lymphoblastic leukemia (ALL). Following high‐throughput miRNA expression analysis (48 samples), five miRs were selected for further confirmation performed by real time quantitative PCR on a cohort of precursor B‐cell ALL patients (n = 138). The results were correlated with clinical parameters and outcome. Low expression of miR‐151‐5p, and miR‐451, and high expression of miR‐1290 or a combination of all three predicted inferior relapse free survival (P = 0.007, 0.042, 0.025, and