Baseline characteristic of patients presenting with lacunar stroke and cerebral small vessel disease may predict future development of depression

Objective Cerebral small vessel disease (SVD) is associated with late‐onset depression and increases the risk for depression after stroke. We aimed to investigate baseline predictors of depression after long‐term follow‐up in patients with SVD, initially presenting with first‐ever lacunar stroke, fr...

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Veröffentlicht in:International journal of geriatric psychiatry 2016-01, Vol.31 (1), p.58-65
Hauptverfasser: Pavlovic, Aleksandra M., Pekmezovic, Tatjana, Zidverc Trajkovic, Jasna, Svabic Medjedovic, Tamara, Veselinovic, Nikola, Radojicic, Aleksandra, Mijajlovic, Milija, Tomic, Gordana, Jovanovic, Zagorka, Norton, Melanie, Sternic, Nada
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Sprache:eng
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Zusammenfassung:Objective Cerebral small vessel disease (SVD) is associated with late‐onset depression and increases the risk for depression after stroke. We aimed to investigate baseline predictors of depression after long‐term follow‐up in patients with SVD, initially presenting with first‐ever lacunar stroke, free of depression and cognitive impairment. Methods A total of 294 patients with SVD were evaluated 3–5 years after the qualifying event. We analyzed baseline demographic data, vascular risk factors, functional status expressed as a score on modified Rankin Scale (mRS), cognitive status, presence of depression, total number of lacunar infarcts and severity of white matter hyperintensities (WMH) on MRI with Age‐Related White Matter Changes scale total score (tARWMC) and Fazekas scale periventricular and deep subcortical scores. Results On follow‐up, depression was registered in 117 (39.8%) SVD patients. At the baseline, patients with depression compared with non‐depressed were older (64.4 vs 60.9 years; p = 0.007), had higher mRS score (2.8 ± 0.7 vs 1.5 ± 0.7; p 
ISSN:0885-6230
1099-1166
DOI:10.1002/gps.4289