Recent advances in dengue pathogenesis and clinical management

Abstract This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune...

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Veröffentlicht in:	Vaccine 2015-12, Vol.33 (50), p.7061-7068
Hauptverfasser:	Simmons, Cameron P, McPherson, Kirsty, Van Vinh Chau, Nguyen, Hoai Tam, D.T, Young, Paul, Mackenzie, Jason, Wills, Bridget
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Allergy and Immunology Antigens Blood platelets Clinical research Dengue Dengue - diagnosis Dengue - epidemiology Dengue - pathology Dengue - therapy Dengue fever Dengue virus Diagnostic Tests, Routine Flaviviridae Host-Pathogen Interactions Humans Immune Evasion Immunity, Cellular Immunity, Humoral Immunity, Innate Immunology Immunotherapy - methods Immunotherapy - trends Infections Laboratories Lymphatic system Lymphocytes Pathogenesis Permeability Respiratory distress syndrome Vaccine Vector-borne diseases Virology
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Beschreibung
Zusammenfassung:	Abstract This review describes and commentates on recent advances in the understanding of dengue pathogenesis and immunity, plus clinical research on vaccines and therapeutics. We expand specifically on the role of the dermis in dengue virus infection, the contribution of cellular and humoral immune responses to pathogenesis and immunity, NS1 and mechanisms of virus immune evasion. Additionally we review a series of therapeutic intervention trials for dengue, as well as recent clinical research aimed at improving clinical diagnosis, risk prediction and disease classification.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2015.09.103