Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

Mutation in the DNA mismatch repair gene homologue hMLH 1 is associated with hereditary non-polyposis colon cancer

A study reports that a human gene encoding a protein, hMLH1 (human MutL homologue), homologous to the bacterial DNA mismatch repair protein MutL, is located on human chromosome 3p21.3-23.

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Veröffentlicht in:Nature (London) 1994-03, Vol.368 (6468), p.258-261
Hauptverfasser: Bronner, C. Eric, Baker, Sean M., Morrison, Paul T., Warren, Gwynedd, Smith, Leslie G., Lescoe, Mary Kay, Kane, Michael, Earabino, Christine, Lipford, James, Lindblom, Annika, Tannergård, Pia, Bollag, Roni J., Godwin, Alan R., Ward, David C., Nordenskj⊘ld, Magnus, Fishel, Richard, Kolodner, Richard, Liskay, R. Michael
Format: Artikel
Sprache:eng
Schlagworte:
Colorectal cancer
Deoxyribonucleic acid
DNA
Genes
Medical research
Mutation
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Beschreibung
Zusammenfassung:A study reports that a human gene encoding a protein, hMLH1 (human MutL homologue), homologous to the bacterial DNA mismatch repair protein MutL, is located on human chromosome 3p21.3-23.
ISSN:0028-0836
1476-4687
DOI:10.1038/368258a0