Evaluation of Ketoprofen Effects on Humoral Immunity and Immune Organs in Mice
The present project was designed to study the effects of ketoprofen on humoral immunity and to evaluate the toxic effects of ketoprofen on immune organs of mice. Effects of ketoprofen on humoral component of immune system were evaluated at two doses 1mg/kg and 5mg/kg by performing haemagglutination...
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| Veröffentlicht in: | Pakistan journal of zoology 2014-12, Vol.46 (6) |
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| creator | Dawood Ahmad Hamdani Aqeel Javeed Ashraf, Muhammad Nazir, Jawad |
| description | The present project was designed to study the effects of ketoprofen on humoral immunity and to evaluate the toxic effects of ketoprofen on immune organs of mice. Effects of ketoprofen on humoral component of immune system were evaluated at two doses 1mg/kg and 5mg/kg by performing haemagglutination assay and mice lethality test. Spleen and thymus were removed from the mice and histopathological examination was performed to observe the toxic effects of ketoprofen on these organs. Ketoprofen treatment exhibited significant (pless than 0.001) decrease in serum anti-SRBCs antibody titer as compared to the control. Mortality ratio was significantly (pless than 0.001) increased in ketoprofen treated mice. There was a significant (p=0.01) decrease in the weight of spleen and thymus in ketoprofen treated groups. Histopathological analysis of spleen of the mice treated with .ketoprofen presented slight increase in the thickness of the trabecular due to odema in spleen. Moreover few medullary changes in the form of mild medullary atrophy occurred in the thymus of mice. These results provide the information that ketoprofen has immunosuppressive effects on humoral immunity therefore it can be used in patients with autoimmune diseases and to prevent allograft rejection. |
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Effects of ketoprofen on humoral component of immune system were evaluated at two doses 1mg/kg and 5mg/kg by performing haemagglutination assay and mice lethality test. Spleen and thymus were removed from the mice and histopathological examination was performed to observe the toxic effects of ketoprofen on these organs. Ketoprofen treatment exhibited significant (pless than 0.001) decrease in serum anti-SRBCs antibody titer as compared to the control. Mortality ratio was significantly (pless than 0.001) increased in ketoprofen treated mice. There was a significant (p=0.01) decrease in the weight of spleen and thymus in ketoprofen treated groups. Histopathological analysis of spleen of the mice treated with .ketoprofen presented slight increase in the thickness of the trabecular due to odema in spleen. Moreover few medullary changes in the form of mild medullary atrophy occurred in the thymus of mice. These results provide the information that ketoprofen has immunosuppressive effects on humoral immunity therefore it can be used in patients with autoimmune diseases and to prevent allograft rejection.</description><identifier>ISSN: 0030-9923</identifier><language>eng</language><publisher>Lahore: Knowledge Bylanes</publisher><subject>Dosage and administration ; Drug interactions ; Immune response ; Immunological research ; Ketoprofen ; Pharmaceutical research</subject><ispartof>Pakistan journal of zoology, 2014-12, Vol.46 (6)</ispartof><rights>COPYRIGHT 2014 Knowledge Bylanes</rights><rights>Copyright 2014 Pakistan Journal of Zoology</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids></links><search><creatorcontrib>Dawood Ahmad Hamdani</creatorcontrib><creatorcontrib>Aqeel Javeed</creatorcontrib><creatorcontrib>Ashraf, Muhammad</creatorcontrib><creatorcontrib>Nazir, Jawad</creatorcontrib><title>Evaluation of Ketoprofen Effects on Humoral Immunity and Immune Organs in Mice</title><title>Pakistan journal of zoology</title><description>The present project was designed to study the effects of ketoprofen on humoral immunity and to evaluate the toxic effects of ketoprofen on immune organs of mice. Effects of ketoprofen on humoral component of immune system were evaluated at two doses 1mg/kg and 5mg/kg by performing haemagglutination assay and mice lethality test. Spleen and thymus were removed from the mice and histopathological examination was performed to observe the toxic effects of ketoprofen on these organs. Ketoprofen treatment exhibited significant (pless than 0.001) decrease in serum anti-SRBCs antibody titer as compared to the control. Mortality ratio was significantly (pless than 0.001) increased in ketoprofen treated mice. There was a significant (p=0.01) decrease in the weight of spleen and thymus in ketoprofen treated groups. Histopathological analysis of spleen of the mice treated with .ketoprofen presented slight increase in the thickness of the trabecular due to odema in spleen. Moreover few medullary changes in the form of mild medullary atrophy occurred in the thymus of mice. These results provide the information that ketoprofen has immunosuppressive effects on humoral immunity therefore it can be used in patients with autoimmune diseases and to prevent allograft rejection.</description><subject>Dosage and administration</subject><subject>Drug interactions</subject><subject>Immune response</subject><subject>Immunological research</subject><subject>Ketoprofen</subject><subject>Pharmaceutical research</subject><issn>0030-9923</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNptjk1LAzEQhnNQsNT-h4AXLyvZZPN1LKXa4kcvel7S7KSk7Ca6yQr-eyMVFHHmMMzMM--8Z2hGCCOV1pRdoEVKR1KiEZxSNUNP63fTTyb7GHB0-B5yfB2jg4DXzoHNCZfFZhriaHq8HYYp-PyBTehODeDdeDAhYR_wo7dwic6d6RMsvuscvdyun1eb6mF3t10tH6oDVSxXnAjdMUeM5kBqoaQjgkljNJOWC1FbCrLZE9qwjnSg9goEszV0Tc0I5xrYHF2fdIvZtwlSbgefLPS9CRCn1NZSCsGZkKqgV3_QY5zGUNwVinDVUKnJD3UwPbQ-uJhHY79E2yXTTU2kLM_n6OYfqmQHg7cxgPNl_uvgE1Z0cck</recordid><startdate>20141201</startdate><enddate>20141201</enddate><creator>Dawood Ahmad Hamdani</creator><creator>Aqeel Javeed</creator><creator>Ashraf, Muhammad</creator><creator>Nazir, Jawad</creator><general>Knowledge Bylanes</general><general>AsiaNet Pakistan (Pvt) Ltd</general><scope>7QG</scope><scope>7SS</scope><scope>7XB</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>AFKRA</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>LK8</scope><scope>M2P</scope><scope>M7P</scope><scope>P64</scope><scope>PATMY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PYCSY</scope><scope>Q9U</scope><scope>RC3</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20141201</creationdate><title>Evaluation of Ketoprofen Effects on Humoral Immunity and Immune Organs in Mice</title><author>Dawood Ahmad Hamdani ; 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Effects of ketoprofen on humoral component of immune system were evaluated at two doses 1mg/kg and 5mg/kg by performing haemagglutination assay and mice lethality test. Spleen and thymus were removed from the mice and histopathological examination was performed to observe the toxic effects of ketoprofen on these organs. Ketoprofen treatment exhibited significant (pless than 0.001) decrease in serum anti-SRBCs antibody titer as compared to the control. Mortality ratio was significantly (pless than 0.001) increased in ketoprofen treated mice. There was a significant (p=0.01) decrease in the weight of spleen and thymus in ketoprofen treated groups. Histopathological analysis of spleen of the mice treated with .ketoprofen presented slight increase in the thickness of the trabecular due to odema in spleen. Moreover few medullary changes in the form of mild medullary atrophy occurred in the thymus of mice. These results provide the information that ketoprofen has immunosuppressive effects on humoral immunity therefore it can be used in patients with autoimmune diseases and to prevent allograft rejection.</abstract><cop>Lahore</cop><pub>Knowledge Bylanes</pub></addata></record> |
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| ispartof | Pakistan journal of zoology, 2014-12, Vol.46 (6) |
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| language | eng |
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| source | EZB-FREE-00999 freely available EZB journals |
| subjects | Dosage and administration Drug interactions Immune response Immunological research Ketoprofen Pharmaceutical research |
| title | Evaluation of Ketoprofen Effects on Humoral Immunity and Immune Organs in Mice |
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