Xenografts Supplemented with Pamindronate placed in postextraction sockets to avoid crestal bone resorption. Experimental study in Fox hound dogs

Objectives The aim of the study was to compare the effects of porcine xenografts (MP3®) with or without pamindronate for the healing of small and large defects of postextraction sockets. Materials and methods Six beagle dogs were used in the study; second premolars and first molars of the mandible were extracted, small defects (SD) and large defects (LD) were identified. Each defect was measured and randomly filled as follows: SC (small control defects filled with MP3® alone), ST (small test defects filled with MP3® modified with pamindronate), LC (large control defects filled with MP3® alone), LT (large test defects filled with MP3® modified with pamindronate). After 4 and 8 weeks, the animals were euthanized and the percentages of new bone formation (NB), residual graft (RG) and connective tissue (CT) were analysed by histology and histomorphometry of undecalcified samples. Results After 4 weeks, NB formation was higher for ST compared to all groups and for LT compared to LC (P