Leukocyte production of IFN-γ and TNF-α in 8- to 12-y-old children with low serum iron levels

Abstract Objective Iron deficiency is likely the most common nutritional deficiency worldwide; low iron concentrations have been related to alterations in immune system functions; therefore, the aim of this study was to determine the effect of low serum iron (LSI) concentrations on the production of...

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Veröffentlicht in:	Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2016-05, Vol.32 (5), p.546-552
Hauptverfasser:	Contreras, Irazú, Ph.D, Paredes-Cervantes, Vladimir, D.Sc, García-Miranda, Luis A., B.Sc, Pliego-Rivero, Francisco Bernardo, Ph.D, Estrada, José A., Ph.D
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia, Iron-Deficiency - blood Anemia, Iron-Deficiency - immunology Anemia, Iron-Deficiency - metabolism Anemia, Iron-Deficiency - physiopathology Asymptomatic Diseases Blood Cell Count C-Reactive Protein - analysis Calcium Ionophores - pharmacology Child Child Nutritional Physiological Phenomena Cytokines Female Ferritins - blood Gastroenterology and Hepatology Humans Immune response Interferon-gamma - biosynthesis Interferon-gamma - blood Interferon-gamma - secretion Ionomycin - pharmacology Iron - blood Leukocytes Leukocytes, Mononuclear - drug effects Leukocytes, Mononuclear - immunology Leukocytes, Mononuclear - metabolism Leukocytes, Mononuclear - secretion Leukocytosis - etiology Lipopolysaccharides - pharmacology Low serum iron Male Mexico Mitogens - pharmacology Tetradecanoylphorbol Acetate - analogs & derivatives Tetradecanoylphorbol Acetate - pharmacology Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - secretion
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Zusammenfassung:	Abstract Objective Iron deficiency is likely the most common nutritional deficiency worldwide; low iron concentrations have been related to alterations in immune system functions; therefore, the aim of this study was to determine the effect of low serum iron (LSI) concentrations on the production of proinflammatory cytokines by peripheral blood leukocytes in 8- to 12-y-old children from a local community. Methods We obtained 120 blood samples and determined full blood counts and serum iron concentrations. An LSI and a control group, paired by age and sex were established using serum iron
ISSN:	0899-9007 1873-1244
DOI:	10.1016/j.nut.2015.11.005