TPRV-1 expression in human preeclamptic placenta

Highlights • TRPV-1 mRNA expression increases in preeclamptic placentas. • TRPV-1 protein expression decreases in preeclamptic placentas. • TRPV-1 was detectable at very low levels in trophoblast cells of preeclamptic placentas. • The decrease in TRPV-1 protein expression may correlate with dysfunct...

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Veröffentlicht in:	Placenta (Eastbourne) 2016-04, Vol.40, p.25-28
Hauptverfasser:	Martínez, Nora, Abán, Cyntia E, Leguizamón, Gustavo F, Damiano, Alicia E, Farina, Mariana G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Case-Control Studies Female Humans Internal Medicine Obstetrics and Gynecology Placenta - metabolism Pre-Eclampsia - metabolism Preeclampsia Pregnancy Trophoblast TRPV Cation Channels - metabolism TRPV-1 Young Adult
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Zusammenfassung:	Highlights • TRPV-1 mRNA expression increases in preeclamptic placentas. • TRPV-1 protein expression decreases in preeclamptic placentas. • TRPV-1 was detectable at very low levels in trophoblast cells of preeclamptic placentas. • The decrease in TRPV-1 protein expression may correlate with dysfunctional transplacental Ca2+ exchange observed in preeclampsia.
ISSN:	0143-4004 1532-3102
DOI:	10.1016/j.placenta.2016.02.008