Symptomatic Dengue in Children in 10 Asian and Latin American Countries

Dengue is a vectorborne viral infection with periods of rapid transmission. By combining placebo groups from vaccine-efficacy trials, the authors were able to estimate the burden of symptomatic dengue infection in children across 10 Asian and Latin American countries. In the past several decades, the burden of dengue has expanded to place almost 3.9 billion people at risk for infection. 1 , 2 From an evidence-based global map, it was estimated that 390 million infections occur annually, 96 million of which are symptomatic. 1 Furthermore, dengue is essentially endemic throughout the tropics and has expanded into 128 countries as dengue virus serotypes continue to spread into new areas. 2 In areas where dengue is endemic, all populations and age groups are at risk, and the burden of cases that require hospitalization can be substantial, especially during outbreaks, with attendant strains on health care . . .