SOX7 is associated with the suppression of human glioma by HMG-box dependent regulation of Wnt/β-catenin signaling

Highlights • Loss of SOX7 expression was found in human glioma. • SOX7 related Wnt/β-catenin signaling upregulation plays an important role in glioma progression. • HMG-box is a key domain of SOX7 for negatively regulating the Wnt/β-catenin signaling pathway.

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Bibliographische Detailangaben
Veröffentlicht in:	Cancer letters 2016-05, Vol.375 (1), p.100-107
Hauptverfasser:	Zhao, Tianshu, Yang, Hui, Tian, Yu, Xie, Qing, Lu, Yun, Wang, Yu, Su, Ning, Dong, Baijing, Liu, Xian, Wang, Ce, Jiang, Chuanlu, Liu, Qianxiao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animals Binding Sites Brain Neoplasms - metabolism Carcinogenesis Cell Line, Tumor Cell Proliferation Down-Regulation Female Gene Expression Regulation, Neoplastic Glioma Glioma - metabolism Hematology, Oncology and Palliative Medicine Humans Male Mice, Nude Middle Aged Neoplasm Transplantation Protein Structure, Tertiary SOX7 SOXF Transcription Factors - physiology Tumor suppressor Wnt Signaling Pathway Wnt/β-catenin
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Beschreibung
Zusammenfassung:	Highlights • Loss of SOX7 expression was found in human glioma. • SOX7 related Wnt/β-catenin signaling upregulation plays an important role in glioma progression. • HMG-box is a key domain of SOX7 for negatively regulating the Wnt/β-catenin signaling pathway.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2016.02.044