Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer
Purpose Sarcopenia is suggested to be associated with cancer-related inflammation. We assessed the clinical outcome of small cell lung cancer (SCLC) patients according to sarcopenia and the neutrophil-to-lymphocyte ratio (NLR). Methods A total of 117 male SCLC patients treated with first-line chemo-...
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creator | Go, Se-Il Park, Mi Jung Song, Haa-Na Kang, Myoung Hee Park, Hee Jung Jeon, Kyung Nyeo Kim, Seok-Hyun Kim, Moon Jin Kang, Jung-Hun Lee, Gyeong-Won |
description | Purpose
Sarcopenia is suggested to be associated with cancer-related inflammation. We assessed the clinical outcome of small cell lung cancer (SCLC) patients according to sarcopenia and the neutrophil-to-lymphocyte ratio (NLR).
Methods
A total of 117 male SCLC patients treated with first-line chemo- or chemoradiotherapy were assessed based on a retrospective chart review. The mass of the pectoralis muscle was measured by computed tomography and normalized to height. Patients with the lowest quartile of muscle mass were considered to have sarcopenia. Patients were classified into four groups according to their sarcopenia and NLR statuses: sarcopenia/high NLR, sarcopenia/low NLR, non-sarcopenia/high NLR, and non-sarcopenia/low NLR.
Results
Sarcopenic patients had lower progression-free survival (PFS) than did non-sarcopenic patients (median 6.0 vs. 7.5 months,
p
= 0.009), but the difference in overall survival (OS) was not statistically significant (median 10.5 vs. 13.5 months,
p
= 0.052). However, the OS of sarcopenic patients with high NLR was significantly lower than that in all other groups (median 3.2 vs. 16.0 vs. 12.5 vs. 13.7 months, respectively,
p
|
doi_str_mv | 10.1007/s00520-015-2997-x |
format | Article |
fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_1776088937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A447313545</galeid><sourcerecordid>A447313545</sourcerecordid><originalsourceid>FETCH-LOGICAL-c439t-2221a84ef17c9e58f374b29433c336b6289fa6e3e6b5309732c52ab5a89cd7c73</originalsourceid><addsrcrecordid>eNp1kUtv1TAQhSMEoreFH8AGWWLDJsXPOF5WVYFKlVgAa8txJhdXiR3spI8Vf52JbnkKZMmWxt85mplTVS8YPWWU6jeFUsVpTZmquTG6vntU7ZgUotZCmMfVjhrJaimUOqqOS7mmlGmt-NPqiDdKNlI1u-rbR5d9miEGR1zsSYjD6KbJLSFF4jJgoQf87iEuZM7QB7-kXEgaSFnzTbhxIyJkciOQGVWIFRLhdrwnfXD7mAr05DYsX0hBZiQe8BrXuCfeRQ_5WfVkcGOB5w_vSfX57cWn8_f11Yd3l-dnV7WXwiw155y5VsLAtDeg2kFo2XGDs3ohmq7hrRlcAwKaTglqtOBecdcp1xrfa6_FSfX64Dvn9HWFstgplK0ZFyGtxeJmGtq2Rmzoq7_Q67TmiN1tFNq3LRW_qD2ObnFtacnOb6b2TEotmFBSIXX6DwpPD1PwKcIQsP6HgB0EPqdSMgx2zmFy-d4yarfQ7SF0i6HbLXR7h5qXDw2v3QT9T8WPlBHgB6DgV9xD_m2i_7p-BwDat2U</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1775308803</pqid></control><display><type>article</type><title>Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Go, Se-Il ; Park, Mi Jung ; Song, Haa-Na ; Kang, Myoung Hee ; Park, Hee Jung ; Jeon, Kyung Nyeo ; Kim, Seok-Hyun ; Kim, Moon Jin ; Kang, Jung-Hun ; Lee, Gyeong-Won</creator><creatorcontrib>Go, Se-Il ; Park, Mi Jung ; Song, Haa-Na ; Kang, Myoung Hee ; Park, Hee Jung ; Jeon, Kyung Nyeo ; Kim, Seok-Hyun ; Kim, Moon Jin ; Kang, Jung-Hun ; Lee, Gyeong-Won</creatorcontrib><description>Purpose
Sarcopenia is suggested to be associated with cancer-related inflammation. We assessed the clinical outcome of small cell lung cancer (SCLC) patients according to sarcopenia and the neutrophil-to-lymphocyte ratio (NLR).
Methods
A total of 117 male SCLC patients treated with first-line chemo- or chemoradiotherapy were assessed based on a retrospective chart review. The mass of the pectoralis muscle was measured by computed tomography and normalized to height. Patients with the lowest quartile of muscle mass were considered to have sarcopenia. Patients were classified into four groups according to their sarcopenia and NLR statuses: sarcopenia/high NLR, sarcopenia/low NLR, non-sarcopenia/high NLR, and non-sarcopenia/low NLR.
Results
Sarcopenic patients had lower progression-free survival (PFS) than did non-sarcopenic patients (median 6.0 vs. 7.5 months,
p
= 0.009), but the difference in overall survival (OS) was not statistically significant (median 10.5 vs. 13.5 months,
p
= 0.052). However, the OS of sarcopenic patients with high NLR was significantly lower than that in all other groups (median 3.2 vs. 16.0 vs. 12.5 vs. 13.7 months, respectively,
p
< 0.001), as was PFS (median 3.2 vs. 7.7 vs. 7.6 vs. 7.1 months, respectively,
p
< 0.001). On multivariate analysis, sarcopenia with high NLR was an independent prognostic factor for shorter PFS and OS. Early discontinuation of treatment (20.0 vs. 10.3 %) and treatment-related mortality (50.0 vs. 8.4 %) occurred more frequently in these patients than in the other groups (
p
< 0.001).
Conclusions
In SCLC, sarcopenic male patients with high NLR have a poor prognosis and do not tolerate standard treatment. Intensive supportive care is needed in these patients.</description><identifier>ISSN: 0941-4355</identifier><identifier>EISSN: 1433-7339</identifier><identifier>DOI: 10.1007/s00520-015-2997-x</identifier><identifier>PMID: 26546456</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cancer ; Care and treatment ; Chemoradiotherapy - mortality ; Chemotherapy ; CT imaging ; Development and progression ; Diagnostic imaging ; Disease-Free Survival ; Female ; Follow-Up Studies ; Humans ; Inflammation ; Inflammation - mortality ; Inflammation - pathology ; Lung cancer ; Lung cancer, Small cell ; Lung Neoplasms - drug therapy ; Lung Neoplasms - mortality ; Lung Neoplasms - physiopathology ; Lymphocytes ; Male ; Medical colleges ; Medical prognosis ; Medicine ; Medicine & Public Health ; Middle Aged ; Neutrophils - drug effects ; Nursing ; Nursing Research ; Oncology ; Original Article ; Pain Medicine ; Patient outcomes ; Prognosis ; Rehabilitation Medicine ; Retrospective Studies ; Sarcopenia ; Sarcopenia - mortality ; Sarcopenia - pathology ; Small Cell Lung Carcinoma - drug therapy ; Small Cell Lung Carcinoma - mortality ; Small Cell Lung Carcinoma - physiopathology</subject><ispartof>Supportive care in cancer, 2016-05, Vol.24 (5), p.2075-2084</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>COPYRIGHT 2016 Springer</rights><rights>Springer-Verlag Berlin Heidelberg 2016</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-2221a84ef17c9e58f374b29433c336b6289fa6e3e6b5309732c52ab5a89cd7c73</citedby><cites>FETCH-LOGICAL-c439t-2221a84ef17c9e58f374b29433c336b6289fa6e3e6b5309732c52ab5a89cd7c73</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00520-015-2997-x$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00520-015-2997-x$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26546456$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Go, Se-Il</creatorcontrib><creatorcontrib>Park, Mi Jung</creatorcontrib><creatorcontrib>Song, Haa-Na</creatorcontrib><creatorcontrib>Kang, Myoung Hee</creatorcontrib><creatorcontrib>Park, Hee Jung</creatorcontrib><creatorcontrib>Jeon, Kyung Nyeo</creatorcontrib><creatorcontrib>Kim, Seok-Hyun</creatorcontrib><creatorcontrib>Kim, Moon Jin</creatorcontrib><creatorcontrib>Kang, Jung-Hun</creatorcontrib><creatorcontrib>Lee, Gyeong-Won</creatorcontrib><title>Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer</title><title>Supportive care in cancer</title><addtitle>Support Care Cancer</addtitle><addtitle>Support Care Cancer</addtitle><description>Purpose
Sarcopenia is suggested to be associated with cancer-related inflammation. We assessed the clinical outcome of small cell lung cancer (SCLC) patients according to sarcopenia and the neutrophil-to-lymphocyte ratio (NLR).
Methods
A total of 117 male SCLC patients treated with first-line chemo- or chemoradiotherapy were assessed based on a retrospective chart review. The mass of the pectoralis muscle was measured by computed tomography and normalized to height. Patients with the lowest quartile of muscle mass were considered to have sarcopenia. Patients were classified into four groups according to their sarcopenia and NLR statuses: sarcopenia/high NLR, sarcopenia/low NLR, non-sarcopenia/high NLR, and non-sarcopenia/low NLR.
Results
Sarcopenic patients had lower progression-free survival (PFS) than did non-sarcopenic patients (median 6.0 vs. 7.5 months,
p
= 0.009), but the difference in overall survival (OS) was not statistically significant (median 10.5 vs. 13.5 months,
p
= 0.052). However, the OS of sarcopenic patients with high NLR was significantly lower than that in all other groups (median 3.2 vs. 16.0 vs. 12.5 vs. 13.7 months, respectively,
p
< 0.001), as was PFS (median 3.2 vs. 7.7 vs. 7.6 vs. 7.1 months, respectively,
p
< 0.001). On multivariate analysis, sarcopenia with high NLR was an independent prognostic factor for shorter PFS and OS. Early discontinuation of treatment (20.0 vs. 10.3 %) and treatment-related mortality (50.0 vs. 8.4 %) occurred more frequently in these patients than in the other groups (
p
< 0.001).
Conclusions
In SCLC, sarcopenic male patients with high NLR have a poor prognosis and do not tolerate standard treatment. Intensive supportive care is needed in these patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Chemoradiotherapy - mortality</subject><subject>Chemotherapy</subject><subject>CT imaging</subject><subject>Development and progression</subject><subject>Diagnostic imaging</subject><subject>Disease-Free Survival</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation - mortality</subject><subject>Inflammation - pathology</subject><subject>Lung cancer</subject><subject>Lung cancer, Small cell</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - mortality</subject><subject>Lung Neoplasms - physiopathology</subject><subject>Lymphocytes</subject><subject>Male</subject><subject>Medical colleges</subject><subject>Medical prognosis</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neutrophils - drug effects</subject><subject>Nursing</subject><subject>Nursing Research</subject><subject>Oncology</subject><subject>Original Article</subject><subject>Pain Medicine</subject><subject>Patient outcomes</subject><subject>Prognosis</subject><subject>Rehabilitation Medicine</subject><subject>Retrospective Studies</subject><subject>Sarcopenia</subject><subject>Sarcopenia - mortality</subject><subject>Sarcopenia - pathology</subject><subject>Small Cell Lung Carcinoma - drug therapy</subject><subject>Small Cell Lung Carcinoma - mortality</subject><subject>Small Cell Lung Carcinoma - physiopathology</subject><issn>0941-4355</issn><issn>1433-7339</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2016</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp1kUtv1TAQhSMEoreFH8AGWWLDJsXPOF5WVYFKlVgAa8txJhdXiR3spI8Vf52JbnkKZMmWxt85mplTVS8YPWWU6jeFUsVpTZmquTG6vntU7ZgUotZCmMfVjhrJaimUOqqOS7mmlGmt-NPqiDdKNlI1u-rbR5d9miEGR1zsSYjD6KbJLSFF4jJgoQf87iEuZM7QB7-kXEgaSFnzTbhxIyJkciOQGVWIFRLhdrwnfXD7mAr05DYsX0hBZiQe8BrXuCfeRQ_5WfVkcGOB5w_vSfX57cWn8_f11Yd3l-dnV7WXwiw155y5VsLAtDeg2kFo2XGDs3ohmq7hrRlcAwKaTglqtOBecdcp1xrfa6_FSfX64Dvn9HWFstgplK0ZFyGtxeJmGtq2Rmzoq7_Q67TmiN1tFNq3LRW_qD2ObnFtacnOb6b2TEotmFBSIXX6DwpPD1PwKcIQsP6HgB0EPqdSMgx2zmFy-d4yarfQ7SF0i6HbLXR7h5qXDw2v3QT9T8WPlBHgB6DgV9xD_m2i_7p-BwDat2U</recordid><startdate>20160501</startdate><enddate>20160501</enddate><creator>Go, Se-Il</creator><creator>Park, Mi Jung</creator><creator>Song, Haa-Na</creator><creator>Kang, Myoung Hee</creator><creator>Park, Hee Jung</creator><creator>Jeon, Kyung Nyeo</creator><creator>Kim, Seok-Hyun</creator><creator>Kim, Moon Jin</creator><creator>Kang, Jung-Hun</creator><creator>Lee, Gyeong-Won</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>0-V</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88J</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ALSLI</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HEHIP</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2R</scope><scope>M2S</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20160501</creationdate><title>Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer</title><author>Go, Se-Il ; Park, Mi Jung ; Song, Haa-Na ; Kang, Myoung Hee ; Park, Hee Jung ; Jeon, Kyung Nyeo ; Kim, Seok-Hyun ; Kim, Moon Jin ; Kang, Jung-Hun ; Lee, Gyeong-Won</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-2221a84ef17c9e58f374b29433c336b6289fa6e3e6b5309732c52ab5a89cd7c73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2016</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Chemoradiotherapy - mortality</topic><topic>Chemotherapy</topic><topic>CT imaging</topic><topic>Development and progression</topic><topic>Diagnostic imaging</topic><topic>Disease-Free Survival</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation - mortality</topic><topic>Inflammation - pathology</topic><topic>Lung cancer</topic><topic>Lung cancer, Small cell</topic><topic>Lung Neoplasms - drug therapy</topic><topic>Lung Neoplasms - mortality</topic><topic>Lung Neoplasms - physiopathology</topic><topic>Lymphocytes</topic><topic>Male</topic><topic>Medical colleges</topic><topic>Medical prognosis</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neutrophils - drug effects</topic><topic>Nursing</topic><topic>Nursing Research</topic><topic>Oncology</topic><topic>Original Article</topic><topic>Pain Medicine</topic><topic>Patient outcomes</topic><topic>Prognosis</topic><topic>Rehabilitation Medicine</topic><topic>Retrospective Studies</topic><topic>Sarcopenia</topic><topic>Sarcopenia - mortality</topic><topic>Sarcopenia - pathology</topic><topic>Small Cell Lung Carcinoma - drug therapy</topic><topic>Small Cell Lung Carcinoma - mortality</topic><topic>Small Cell Lung Carcinoma - physiopathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Go, Se-Il</creatorcontrib><creatorcontrib>Park, Mi Jung</creatorcontrib><creatorcontrib>Song, Haa-Na</creatorcontrib><creatorcontrib>Kang, Myoung Hee</creatorcontrib><creatorcontrib>Park, Hee Jung</creatorcontrib><creatorcontrib>Jeon, Kyung Nyeo</creatorcontrib><creatorcontrib>Kim, Seok-Hyun</creatorcontrib><creatorcontrib>Kim, Moon Jin</creatorcontrib><creatorcontrib>Kang, Jung-Hun</creatorcontrib><creatorcontrib>Lee, Gyeong-Won</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Social Sciences Premium Collection</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Social Science Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Social Science Premium Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Sociology Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Social Science Database</collection><collection>Sociology Database (ProQuest)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Supportive care in cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Go, Se-Il</au><au>Park, Mi Jung</au><au>Song, Haa-Na</au><au>Kang, Myoung Hee</au><au>Park, Hee Jung</au><au>Jeon, Kyung Nyeo</au><au>Kim, Seok-Hyun</au><au>Kim, Moon Jin</au><au>Kang, Jung-Hun</au><au>Lee, Gyeong-Won</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer</atitle><jtitle>Supportive care in cancer</jtitle><stitle>Support Care Cancer</stitle><addtitle>Support Care Cancer</addtitle><date>2016-05-01</date><risdate>2016</risdate><volume>24</volume><issue>5</issue><spage>2075</spage><epage>2084</epage><pages>2075-2084</pages><issn>0941-4355</issn><eissn>1433-7339</eissn><abstract>Purpose
Sarcopenia is suggested to be associated with cancer-related inflammation. We assessed the clinical outcome of small cell lung cancer (SCLC) patients according to sarcopenia and the neutrophil-to-lymphocyte ratio (NLR).
Methods
A total of 117 male SCLC patients treated with first-line chemo- or chemoradiotherapy were assessed based on a retrospective chart review. The mass of the pectoralis muscle was measured by computed tomography and normalized to height. Patients with the lowest quartile of muscle mass were considered to have sarcopenia. Patients were classified into four groups according to their sarcopenia and NLR statuses: sarcopenia/high NLR, sarcopenia/low NLR, non-sarcopenia/high NLR, and non-sarcopenia/low NLR.
Results
Sarcopenic patients had lower progression-free survival (PFS) than did non-sarcopenic patients (median 6.0 vs. 7.5 months,
p
= 0.009), but the difference in overall survival (OS) was not statistically significant (median 10.5 vs. 13.5 months,
p
= 0.052). However, the OS of sarcopenic patients with high NLR was significantly lower than that in all other groups (median 3.2 vs. 16.0 vs. 12.5 vs. 13.7 months, respectively,
p
< 0.001), as was PFS (median 3.2 vs. 7.7 vs. 7.6 vs. 7.1 months, respectively,
p
< 0.001). On multivariate analysis, sarcopenia with high NLR was an independent prognostic factor for shorter PFS and OS. Early discontinuation of treatment (20.0 vs. 10.3 %) and treatment-related mortality (50.0 vs. 8.4 %) occurred more frequently in these patients than in the other groups (
p
< 0.001).
Conclusions
In SCLC, sarcopenic male patients with high NLR have a poor prognosis and do not tolerate standard treatment. Intensive supportive care is needed in these patients.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26546456</pmid><doi>10.1007/s00520-015-2997-x</doi><tpages>10</tpages></addata></record> |
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subjects | Adult Aged Aged, 80 and over Cancer Care and treatment Chemoradiotherapy - mortality Chemotherapy CT imaging Development and progression Diagnostic imaging Disease-Free Survival Female Follow-Up Studies Humans Inflammation Inflammation - mortality Inflammation - pathology Lung cancer Lung cancer, Small cell Lung Neoplasms - drug therapy Lung Neoplasms - mortality Lung Neoplasms - physiopathology Lymphocytes Male Medical colleges Medical prognosis Medicine Medicine & Public Health Middle Aged Neutrophils - drug effects Nursing Nursing Research Oncology Original Article Pain Medicine Patient outcomes Prognosis Rehabilitation Medicine Retrospective Studies Sarcopenia Sarcopenia - mortality Sarcopenia - pathology Small Cell Lung Carcinoma - drug therapy Small Cell Lung Carcinoma - mortality Small Cell Lung Carcinoma - physiopathology |
title | Sarcopenia and inflammation are independent predictors of survival in male patients newly diagnosed with small cell lung cancer |
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