The systemic effects of sclerostin overexpression using ΦC31 integrase in mice

Sclerostin, encoded by the Sost gene, is mainly produced by osteocytes in bone and antagonizes the Wnt/β-catenin signaling pathway, which is a requisite for bone formation. Currently, human anti-sclerostin antibodies are being tested in phase III clinical trials. In addition, serum sclerostin levels...

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Veröffentlicht in:	Biochemical and biophysical research communications 2016-04, Vol.472 (3), p.471-476
Hauptverfasser:	Zhang, Dongdong, Park, Bo Mi, Kang, Myengmo, Nam, HeeJin, Kim, Eun Jin, Bae, ChuHyun, Lim, Sung Kil
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bacteriophages - enzymology Bacteriophages - genetics Bone Bone and Bones - metabolism Bone and Bones - pathology Glycoproteins - blood Glycoproteins - genetics Integrases - genetics Male Mice Mice, Inbred ICR Osteoporosis - classification Osteoporosis - pathology Serum sclerostin Sost Transfection - methods Up-Regulation - genetics ΦC31 integrase
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