COMPLEX TRAIT ANALYSIS IN THE MOUSE: The Strengths, The Limitations and The Promise Yet To Come

COMPLEX TRAIT ANALYSIS IN THE MOUSE: The Strengths, The Limitations and The Promise Yet To Come

In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse ( 1 ). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a mo...

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Veröffentlicht in:Annual review of genetics 2000-01, Vol.34 (1), p.653-686
Hauptverfasser: Moore, Karen J, Nagle, Deborah L
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Biological research
Chromosome Mapping
Evaluation
Genes
Genetic research
Genetics
Humans
Laboratory animals
Medical research
Methods
Mice
Models, Animal
mouse
Quantitative genetics
quantitative trait
Quantitative trait loci
Quantitative Trait, Heritable
Rodents
Stem cells
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Zusammenfassung:In 1990, David Baltimore predicted that the 1990s would be the decade of the mouse ( 1 ). This certainly proved to be true: The mouse has contributed immensely to biological research through transgenic, embryonic stem cell (ES) knockout, and classical genetic technologies. But its usefulness as a model organism is by no means over; indeed it is still rising to its peak: The mouse as a model mammalian organism still has much to offer. This article reviews use of the mouse to dissect complex genetic traits using quantitative trait analysis, with a particular emphasis on medically important diseases.
ISSN:0066-4197
1545-2948
DOI:10.1146/annurev.genet.34.1.653