Green Tea Polyphenol Prevents Diabetic Rats From Acute Kidney Injury After Cardiopulmonary Bypass

Background Acute kidney injury (AKI) is a common complication accompanying cardiopulmonary bypass (CPB) and is independently associated with increased morbidity and death. Diabetes mellitus increases the risk for AKI after CPB. Epigallocatechin-3-gallate (EGCG) is a major component of the polyphenol...

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Veröffentlicht in:The Annals of thoracic surgery 2016-04, Vol.101 (4), p.1507-1513
Hauptverfasser: Funamoto, Masaki, MD, Masumoto, Hidetoshi, MD, PhD, Takaori, Koji, MD, Taki, Tomofumi, MD, Setozaki, Shuji, MD, Yamazaki, Kazuhiro, MD, PhD, Minakata, Kenji, MD, PhD, Ikeda, Tadashi, MD, PhD, Hyon, Suong-Hyu, PhD, Sakata, Ryuzo, MD, PhD
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Sprache:eng
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Zusammenfassung:Background Acute kidney injury (AKI) is a common complication accompanying cardiopulmonary bypass (CPB) and is independently associated with increased morbidity and death. Diabetes mellitus increases the risk for AKI after CPB. Epigallocatechin-3-gallate (EGCG) is a major component of the polyphenolic fraction of green tea, which possesses cardioprotective activities, as previously reported. We hypothesized that EGCG also possesses a renoprotective effect through its diverse biochemical properties and assessed the effect on renal function after CPB for diabetic rats. Methods Goto-Kakizaki rats developing type 2 diabetes mellitus were randomly assigned to one of the following groups: sham (n = 10), CPB (CPB alone, n = 9), or EGCG (CPB + EGCG, n = 10). CPB was conducted for 30 minutes at a flow rate of 100 mL/kg/min in the CPB and EGCG groups. Rats assigned to the EGCG group were administrated EGCG solution orally for 2 weeks before CPB. We evaluated renal biochemical or histologic changes at 24 hours after CPB. Results Compared with the CPB group, the EGCG group exhibited milder tubular injury histologically ( p  
ISSN:0003-4975
1552-6259
DOI:10.1016/j.athoracsur.2015.09.080