Transcriptional regulation of the human osteopontin promoter : functional analysis and DNA-protein interactions

Synthesis of cell attachment proteins and cytokines, such as osteopontin (OPN), can promote tumor cell remodeling of the extracellular matrix into an environment that promotes tumor cell attachment and migration. We investigated the transcriptional regulation of OPN in the U-251MG and U-87MG human m...

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Veröffentlicht in:	Oncogene 2000-11, Vol.19 (50), p.5801-5809
Hauptverfasser:	DONGYAN WANG, YAMAMOTO, Shunsuke, HIJIYA, Naoki, BENVENISTE, Etty N, GLADSON, Candece L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibodies, Monoclonal - pharmacology Astrocytes - metabolism Astrocytes - physiology Astrocytoma Astrocytoma - genetics Astrocytoma - metabolism Binding Sites Biological and medical sciences Cell adhesion Cell interactions, adhesion Cell migration Cells Clonal deletion Cytokines Deoxyribonucleic acid DNA DNA biosynthesis DNA, Neoplasm - genetics DNA, Neoplasm - metabolism DNA-Binding Proteins - metabolism E-box-binding factor Extracellular matrix Fundamental and applied biological sciences. Psychology Gene Deletion Gene Expression Regulation, Neoplastic Gene regulation Genetic aspects Genetic regulation Glioma Glucocorticoids Host Cell Factor C1 Humans Molecular and cellular biology Mutagenesis Mutagenesis, Site-Directed Myc protein OCT-1 protein OCT-2 protein Octamer Transcription Factor-1 Octamer Transcription Factor-2 OPN gene Osteopontin Physiological aspects Promoter Regions, Genetic - genetics Promoters (Genetics) Protein biosynthesis Protein interaction Protein-protein interactions Proteins Proto-Oncogene Proteins c-myc - biosynthesis Proto-Oncogene Proteins c-myc - immunology Proto-Oncogene Proteins c-myc - metabolism Rats Regulatory Sequences, Nucleic Acid Sialoglycoproteins - biosynthesis Sialoglycoproteins - genetics Sp1 protein Sp1 Transcription Factor - metabolism Transcription factors Transcription Factors - metabolism Transcription initiation transcription regulation Transcription, Genetic Tumor cells Tumor Cells, Cultured
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