Reply: Nitrites/Nitrates in Heart Failure With Preserved Ejection Fraction

[...]there is also compelling evidence for myocardial nitric oxide deficiency in HFpEF (5), and in this light it is worth noting that nitrite produced significant improvements in left ventricular stroke work on exercise compared with placebo (1). Because stroke work is a measure of pump performance...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Journal of the American College of Cardiology 2016-03, Vol.67 (11), p.1383-1384
Hauptverfasser:	Borlaug, Barry A., Koepp, Katlyn E., Melenovsky, Vojtech
Format:	Artikel
Sprache:	eng
Schlagworte:	Cardiology Exercise Tolerance - drug effects Female Heart failure Heart Failure - physiopathology Heart Ventricles - physiopathology Humans Male Patients Sodium Nitrite - therapeutic use Stroke Volume - drug effects Ventricular Function, Left - drug effects
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	[...]there is also compelling evidence for myocardial nitric oxide deficiency in HFpEF (5), and in this light it is worth noting that nitrite produced significant improvements in left ventricular stroke work on exercise compared with placebo (1). Because stroke work is a measure of pump performance that is independent of arterial afterload, this suggests that there are also direct myocardial effects of nitrite.
ISSN:	0735-1097 1558-3597
DOI:	10.1016/j.jacc.2015.12.055