Modulation of glycolysis and lipogenesis by novel PI3K selective molecule represses tumor angiogenesis and decreases colorectal cancer growth

Highlights • A novel and selective PI3K inhibitor repressed expression of regulatory enzymes of glycolysis and lipogenesis to subdue the flux through these processes in colon cancer. • Metabolic blockage of colon cancer cells led to the inhibition of migration and invasiveness of the cancer. • Furthermore, PI3K inhibition directed glycolytic and lipogenic attenuation halted angiogenesis process. • The inhibitory effects on metabolism and metastatic properties results in colon cancer cell death. It suggests that PI3K mediated inhibition of metabolism-signaling supernetwork of colon cancer cells can be used in anti-angiogenesis and anti-cancer therapies.