Isolation of infectious Zika virus from saliva and prolonged viral RNA shedding in a traveller returning from the Dominican Republic to Italy, January 2016

We report the isolation of infectious Zika virus (ZIKV) in cell culture from the saliva of a patient who developed a febrile illness after returning from the Dominican Republic to Italy, in January 2016. The patient had prolonged shedding of viral RNA in saliva and urine, at higher load than in bloo...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2016-03, Vol.21 (10), p.30159-30159
Hauptverfasser:	Barzon, Luisa, Pacenti, Monia, Berto, Alessandro, Sinigaglia, Alessandro, Franchin, Elisa, Lavezzo, Enrico, Brugnaro, Pierluigi, Palù, Giorgio
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell culture Disease control Dominican Republic Genomes Humans Italy Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Viral - genetics Saliva - virology Sequence Analysis, RNA Travel Virus Shedding Viruses Young Adult Zika Virus - genetics Zika Virus - isolation & purification Zika Virus Infection - diagnosis Zika Virus Infection - virology
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Zusammenfassung:	We report the isolation of infectious Zika virus (ZIKV) in cell culture from the saliva of a patient who developed a febrile illness after returning from the Dominican Republic to Italy, in January 2016. The patient had prolonged shedding of viral RNA in saliva and urine, at higher load than in blood, for up to 29 days after symptom onset. Sequencing of ZIKV genome showed relatedness with strains from Latin America.
ISSN:	1560-7917 1025-496X 1560-7917
DOI:	10.2807/1560-7917.ES.2016.21.10.30159