Roles of Carbonic Anhydrase IX in Development of Pancreatic Cancer

The aim of this study was to study the effects of carbonic anhydrase IX (CA IX) towards the invasion and metastasis of pancreatic cancer. The expressions of CA IX in 58 cases of pancreatic cancer and paired paracancerous normal tissues, obtained from 2005 to 2012 in the first Affiliated Hospital of...

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Veröffentlicht in:	Pathology oncology research 2016-04, Vol.22 (2), p.277-286
Hauptverfasser:	Li, Yuji, Dong, Ming, Sheng, Weiwei, Huang, Longping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antigens, Neoplasm - genetics Antigens, Neoplasm - metabolism Apoptosis Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Blotting, Western Cancer Research Carbonic Anhydrase IX - genetics Carbonic Anhydrase IX - metabolism Cell Movement Cell Proliferation Female Flow Cytometry Follow-Up Studies Humans Immunoenzyme Techniques Immunology Male Neoplasm Invasiveness Neoplasm Staging Oncology Pancreas - enzymology Pancreatic cancer Pancreatic Neoplasms - enzymology Pancreatic Neoplasms - pathology Pathology Prognosis Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - genetics Survival Rate Tumor Cells, Cultured
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Zusammenfassung:	The aim of this study was to study the effects of carbonic anhydrase IX (CA IX) towards the invasion and metastasis of pancreatic cancer. The expressions of CA IX in 58 cases of pancreatic cancer and paired paracancerous normal tissues, obtained from 2005 to 2012 in the first Affiliated Hospital of China Medical University, were detected, as well as its expressions in different pancreatic cancer cell lines, aiming to detect the impacts of CA IX silencing towards the invasion and metastasis of pancreatic cancer cells. The CA IX expressions in 58 pancreatic cancer cases were higher than those in the paired paracancerous normal tissues ( P
ISSN:	1219-4956 1532-2807
DOI:	10.1007/s12253-015-9935-6