Emergence of Multidrug-Resistant Influenza A(H1N1) pdm09 Virus Variants in an Immunocompromised Child Treated With Oseltamivir and Zanamivir

Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase (NA). When phenotypically evaluated by NA inhibition, the dual H275Y-E119G substitution caused highly red...

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Veröffentlicht in:	The Journal of infectious diseases 2015-10, Vol.212 (8), p.1209-1213
Hauptverfasser:	Tamura, Daisuke, DeBiasi, Roberta L., Okomo-Adhiambo, Margaret, Mishin, Vasiliy P., Campbell, Angela P., Loechelt, Brett, Wiedermann, Bernhard L., Fry, Alicia M., Gubareva, Larisa V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Antiviral Agents - therapeutic use Cyclopentanes - therapeutic use Drug Resistance, Viral - genetics Enzyme Inhibitors - therapeutic use Guanidines - therapeutic use Humans Immunocompromised Host Infant Influenza A Virus, H1N1 Subtype - drug effects Influenza A Virus, H1N1 Subtype - genetics Influenza, Human - drug therapy Influenza, Human - virology Male Mutation, Missense Neuraminidase - genetics Oseltamivir - therapeutic use Viral Proteins - genetics VIRUSES Zanamivir - analogs & derivatives Zanamivir - therapeutic use
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Zusammenfassung:	Prolonged treatment of an immunocompromised child with oseltamivir and zanamivir for A(H1N1)pdm09 virus infection led to the emergence of viruses carrying H275Y and/or E119G in the neuraminidase (NA). When phenotypically evaluated by NA inhibition, the dual H275Y-E119G substitution caused highly reduced inhibition by 4 NA inhibitors: oseltamivir, zanamivir, peramivir, and laninamivir.
ISSN:	0022-1899 1537-6613
DOI:	10.1093/infdis/jiv245